The Alzheimer's Association appropriate use recommendations for blood biomarkers in Alzheimer's disease

O Hansson, RM Edelmayer, AL Boxer… - Alzheimer's & …, 2022 - Wiley Online Library
Blood‐based markers (BBMs) have recently shown promise to revolutionize the diagnostic
and prognostic work‐up of Alzheimer's disease (AD), as well as to improve the design of …

Blood-based biomarkers for Alzheimer's disease: Current state and future use in a transformed global healthcare landscape

H Hampel, Y Hu, J Cummings, S Mattke, T Iwatsubo… - Neuron, 2023 - cell.com
Timely detection of the pathophysiological changes and cognitive impairment caused by
Alzheimer's disease (AD) is increasingly pressing because of the advent of biomarker …

Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer's disease

M Milà-Alomà, NJ Ashton, M Shekari, G Salvadó… - Nature medicine, 2022 - nature.com
Blood biomarkers indicating elevated amyloid-β (Aβ) pathology in preclinical Alzheimer's
disease are needed to facilitate the initial screening process of participants in disease …

Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical utility

TK Karikari, NJ Ashton, G Brinkmalm… - Nature Reviews …, 2022 - nature.com
Well-authenticated biomarkers can provide critical insights into the biological basis of
Alzheimer disease (AD) to enable timely and accurate diagnosis, estimate future burden and …

GFAP as a potential biomarker for Alzheimer's disease: a systematic review and meta-analysis

KY Kim, KY Shin, KA Chang - Cells, 2023 - mdpi.com
Blood biomarkers have been considered tools for the diagnosis, prognosis, and monitoring
of Alzheimer's disease (AD). Although amyloid-β peptide (Aβ) and tau are primarily blood …

Plasma phospho-tau in Alzheimer's disease: towards diagnostic and therapeutic trial applications

F Gonzalez-Ortiz, PR Kac, WS Brum… - Molecular …, 2023 - Springer
As the leading cause of dementia, Alzheimer's disease (AD) is a major burden on affected
individuals, their families and caregivers, and healthcare systems. Although AD can be …

Apolipoprotein E in Alzheimer's disease trajectories and the next-generation clinical care pathway

S Narasimhan, DM Holtzman, LG Apostolova… - Nature …, 2024 - nature.com
Alzheimer's disease (AD) is a complex, progressive primary neurodegenerative disease.
Since pivotal genetic studies in 1993, the ε4 allele of the apolipoprotein E gene (APOE ε4) …

Plasma Aβ42/40 ratio, p‐tau181, GFAP, and NfL across the Alzheimer's disease continuum: a cross‐sectional and longitudinal study in the AIBL cohort

P Chatterjee, S Pedrini, JD Doecke… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Plasma amyloid beta (Aβ) 1‐42/Aβ1‐40 ratio, phosphorylated‐tau181 (p‐
tau181), glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) are putative blood …

Predicting amyloid PET and tau PET stages with plasma biomarkers

CR Jack Jr, HJ Wiste, A Algeciras-Schimnich… - Brain, 2023 - academic.oup.com
Staging the severity of Alzheimer's disease pathology using biomarkers is useful for
therapeutic trials and clinical prognosis. Disease staging with amyloid and tau PET has face …

The potential of blood neurofilament light as a marker of neurodegeneration for Alzheimer's disease

Y Jung, JS Damoiseaux - Brain, 2024 - academic.oup.com
Over the past several years, there has been a surge in blood biomarker studies examining
the value of plasma or serum neurofilament light (NfL) as a biomarker of neurodegeneration …