Melatonin is a neurohormone known to modulate a wide range of circadian functions,
including sleep. The synthesis and release of melatonin from the pineal gland is heavily …

Circadian rhythm and the molecules involved in it, such as melanopsin and melatonin, play
an important role in the eye to regulate the homeostasis and even to treat some ocular …

Oxidative stress plays a central role in dry eye disease (DED), which can destroy the mucin
layer on the ocular surface. The currently available eye drops are palliative and short-lived …

Melatonin is not only synthesized by the pineal gland but by several ocular structures. This
natural indoleamine is of great importance for regulating several eye processes, among …

Melanopsin is a non-image forming photoreceptor known to be present in the retina and it is
considered to have light regulated tasks among other functions. In the present work …

Melatonin is a ubiquitous molecule found in living organisms, ranging from bacteria to plants
and mammals. It possesses various properties, partly due to its robust antioxidant nature …

Purpose: Previous studies have reported the presence of a circadian rhythm in PERIOD2::
LUCIFERASE (PER2:: LUC) bioluminescence in mouse photoreceptors, retina, RPE, and …

Introduction The neurohormone melatonin (N-acetyl-5-methoxytryptamine) regulates
circadian rhythms exerting a variety of effects in the central nervous system and in periphery …

Melatonin analogs topically administered evoke a potent tear secretagogue effect in rabbits.
This route of drug administration requires high drug concentration and frequent dosing due …

Oxidative stress, generated because of an imbalance between reactive oxygen species
(ROS) generation and elimination, is associated with lens damage and cataract progression …