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Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation
Z Bekassy, I Lopatko Fagerström, M Bader… - Nature Reviews …, 2022 - nature.com
During severe inflammatory and infectious diseases, various mediators modulate the
equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review …
equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review …
Complement system part I–molecular mechanisms of activation and regulation
Complement is a complex innate immune surveillance system, playing a key role in defense
against pathogens and in host homeostasis. The complement system is initiated by …
against pathogens and in host homeostasis. The complement system is initiated by …
[HTML][HTML] Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a “Kidney Disease: Improving Global Outcomes”(KDIGO) Controversies …
THJ Goodship, HT Cook, F Fakhouri, FC Fervenza… - Kidney international, 2017 - Elsevier
In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G)
complement plays a primary role in disease pathogenesis. Herein we report the outcome of …
complement plays a primary role in disease pathogenesis. Herein we report the outcome of …
Complement system part II: role in immunity
The complement system has been considered for a long time as a simple lytic cascade,
aimed to kill bacteria infecting the host organism. Nowadays, this vision has changed and it …
aimed to kill bacteria infecting the host organism. Nowadays, this vision has changed and it …
[HTML][HTML] Overview of complement activation and regulation
Complement is an important component of the innate immune system that is crucial for
defense from microbial infections and for clearance of immune complexes and injured cells …
defense from microbial infections and for clearance of immune complexes and injured cells …
The pathophysiology of geographic atrophy secondary to age-related macular degeneration and the complement pathway as a therapeutic target
DS Boyer, U Schmidt-Erfurth… - Retina, 2017 - journals.lww.com
Purpose: Geographic atrophy (GA) is an advanced, vision-threatening form of age-related
macular degeneration (AMD) affecting approximately five million individuals worldwide. To …
macular degeneration (AMD) affecting approximately five million individuals worldwide. To …
Complement, a target for therapy in inflammatory and degenerative diseases
The complement system is a key innate immune defence against infection and an important
driver of inflammation; however, these very properties can also cause harm. Inappropriate or …
driver of inflammation; however, these very properties can also cause harm. Inappropriate or …
HUS and atypical HUS
TS Jokiranta - Blood, The Journal of the American Society of …, 2017 - ashpublications.org
Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy characterized by
intravascular hemolysis, thrombocytopenia, and acute kidney failure. HUS is usually …
intravascular hemolysis, thrombocytopenia, and acute kidney failure. HUS is usually …
Complement activation, regulation, and molecular basis for complement‐related diseases
The complement system is an essential element of the innate immune response that
becomes activated upon recognition of molecular patterns associated with microorganisms …
becomes activated upon recognition of molecular patterns associated with microorganisms …
Atypical hemolytic–uremic syndrome
The hemolytic–uremic syndrome, which is characterized by nonimmune hemolytic anemia,
thrombocytopenia, and renal impairment, occurs most frequently in young children. Most …
thrombocytopenia, and renal impairment, occurs most frequently in young children. Most …