Looking at globular proteins with the eyes of a colloid scientist has a long tradition, in fact a
significant part of the early colloid literature was focused on protein solutions. However, it …

In recent years, computational methods have garnered much attention in protein
engineering. A large number of computational methods have been developed to analyze the …

Protein instability leads to reversible self-association and irreversible aggregation which is a
major concern for develo** new biopharmaceutical leads. Protein solution behaviour is …

Attractive protein–protein interactions in concentrated monoclonal antibody (mAb) solutions
may lead to the formation of clusters that increase viscosity. Here, we propose an analytical …

The effects of a subclass of monoclonal antibodies (mAbs) on protein–protein interactions,
formation of reversible oligomers (clusters), and viscosity (η) are not well understood at high …

Antibody therapies are typically based on high-concentration formulations that need to be
administered subcutaneously. These conditions induce several challenges, inter alia a …

Concentrated solutions of monoclonal antibodies have attracted considerable attention due
to their importance in pharmaceutical formulations; yet, their tendency to aggregate and the …

The viscosity of a monoclonal antibody solution must be monitored and controlled as it can
adversely affect product processing, packaging and administration. Engineering low …

Charges and their contribution to protein–protein interactions are essential for the key
structural and dynamic properties of monoclonal antibody (mAb) solutions. In fact, they …

The ability to design and formulate mAbs to minimize attractive interactions at high
concentrations is important for protein processing, stability, and administration, particularly in …