Uncovering the cells and circuits of touch in normal and pathological settings
The sense of touch is fundamental as it provides vital, moment-to-moment information about
the nature of our physical environment. Primary sensory neurons provide the basis for this …
the nature of our physical environment. Primary sensory neurons provide the basis for this …
Identification of lipid heterogeneity and diversity in the develo** human brain
The lipidome is currently understudied but fundamental to life. Within the brain, little is
known about cell-type lipid heterogeneity, and even less is known about cell-to-cell lipid …
known about cell-type lipid heterogeneity, and even less is known about cell-to-cell lipid …
Antagonism of TRPV4 channels partially reduces mechanotransduction in rat skeletal muscle afferents
A Fukazawa, A Hori, N Hotta… - The Journal of …, 2023 - Wiley Online Library
Mechanical distortion of working skeletal muscle induces sympathoexcitation via thin fibre
afferents, a reflex response known as the skeletal muscle mechanoreflex. However, to date …
afferents, a reflex response known as the skeletal muscle mechanoreflex. However, to date …
Single cell profiling using ionic liquid matrix-enhanced secondary ion mass spectrometry for neuronal cell type differentiation
A high-throughput single cell profiling method has been developed for matrix-enhanced-
secondary ion mass spectrometry (ME-SIMS) to investigate the lipid profiles of neuronal …
secondary ion mass spectrometry (ME-SIMS) to investigate the lipid profiles of neuronal …
Nanomedicine-driven neuropathic pain relief in a rat model is associated with macrophage polarity and mast cell activation
We explored the immune neuropathology underlying multi-day relief from neuropathic pain
in a rat model initiated at the sciatic nerve, by using a nanoemulsion-based nanomedicine …
in a rat model initiated at the sciatic nerve, by using a nanoemulsion-based nanomedicine …
Bioinspired scaffold induced regeneration of neural tissue
In the last decade, nerve tissue engineering has attracted much attention due to the
incapability of self-regeneration. Nerve tissue regeneration is mainly based on scaffold …
incapability of self-regeneration. Nerve tissue regeneration is mainly based on scaffold …
A novel multi-modal platform to image molecular and elemental alterations in ischemic stroke
Stroke is a major global health problem, with the prevalence and economic burden
predicted to increase due to aging populations in western society. Following stroke …
predicted to increase due to aging populations in western society. Following stroke …
Role of β-arrestin-2 in short-and long-term opioid tolerance in the dorsal root ganglia
KH Muchhala, JC Jacob, WL Dewey… - European journal of …, 2021 - Elsevier
G-protein-biased agonists with reduced β-arrestin-2 activation are being investigated as
safer alternatives to clinically-used opioids. β-arrestin-2 has been implicated in the …
safer alternatives to clinically-used opioids. β-arrestin-2 has been implicated in the …
Retinal oxidative stress at the onset of diabetes determined by synchrotron FTIR widefield imaging: towards diabetes pathogenesis
Diabetic retinopathy is a microvascular complication of diabetes that can lead to blindness.
In the present study, we aimed to determine the nature of diabetes-induced, highly localized …
In the present study, we aimed to determine the nature of diabetes-induced, highly localized …
FTIR studies of the similarities between pathology induced protein aggregation in vivo and chemically induced protein aggregation ex vivo
Fourier transform infrared (FTIR) spectroscopy has been well documented to discriminate
between protein secondary structures, at the micron scale. This capability has enabled in …
between protein secondary structures, at the micron scale. This capability has enabled in …