Cancer is a prominent cause of death globally. Currently, many drugs that are in clinical
practice are having a high prevalence of side effect and multidrug resistance. Risk of tumors …

Multidrug resistance (MDR) is a serious phenomenon employed by cancer cells which
hampers the success of cancer pharmacotherapy. One of the common mechanisms of MDR …

In arbitrary dimension, in the discrete setting of finite-differences we prove a Carleman
estimate for a semi-discrete parabolic operator, in which the large parameter is connected to …

Uptake and efflux transporters determine plasma and tissue concentrations of a broad
variety of drugs. They are localized in organs such as small intestine, liver, and kidney …

Active drug efflux transporters of the ATP binding cassette (ABC)-containing family of
proteins have a major impact on the pharmacological behavior of most of the drugs in use …

In tumor cell lines, multidrug resistance is often associated with an ATP-dependent decrease
in cellular drug accumulation which is attributed to the overexpression of certain ATP …

The human multidrug resistance-associated protein (MRP) family currently has seven
members. The ability of several of these membrane proteins to transport a wide range of …

Molecular medicine has led to rapid advances in the characterization of hepatobiliary
transport systems that determine the uptake and excretion of bile salts and other biliary …

The acquisition of multidrug resistance is a serious impediment to improved healthcare.
Multidrug resistance is most frequently due to active transporters that pump a broad …

The formation of bile is a vital function, and its impairment by drugs or infectious,
autoimmune, metabolic, or genetic disorders results in the syndrome commonly known as …