Recent studies have determined that the nervous system can sense and respond to signals
from skeletal tissue, a process known as skeletal interoception, which is crucial for …

Somatosensory afferents are traditionally classified by soma size, myelination, and their
response specificity to external and internal stimuli. Here, we propose the functional …

The versatility of somatosensation arises from heterogeneous dorsal root ganglion (DRG)
neurons. However, soma transcriptomes of individual human (h) DRG neurons—critical …

Sensory neurons in the dorsal root ganglion (DRG) and trigeminal ganglion (TG) are
specialized to detect and transduce diverse environmental stimuli to the central nervous …

The corpus cavernosum is the most important structure for penile erection, and its
dysfunction causes many physiological and psychological problems. However, its cellular …

Diabetic neuropathic pain (DNP) is a common and devastating complication in patients with
diabetes. The mechanisms mediating DNP are not completely elucidated, and effective …

Pain is an unpleasant but essential-to-life sensation, usually resulting from tissue damage.
When pain persists long after the injury has resolved, it becomes pathological. The precise …

The ability to feel the warmth of the sun or the coolness of a breeze on a summer's day; a
pleasant caress of skin; to explore the texture, size, and shape of an object; and to feel pain …

Preclinical studies have identified glial cells as pivotal players in the genesis and
maintenance of neuropathic pain after nerve injury associated with diabetes, chemotherapy …

Single-cell RNA sequencing (scRNA-seq) has allowed profiling cell types of the dorsal root
ganglia (DRG) and their transcriptional states in physiology and chronic pain. However, the …