Hydrogen exchange coupled to mass spectrometry (MS) has become a valuable analytical
tool for the study of protein dynamics. By combining information about protein dynamics with …

Conformational changes and protein dynamics play an important role in the catalytic
efficiency of enzymes. Amide H/D exchange mass spectrometry (H/D exchange MS) is …

A Fourier deconvolution method has been developed to explicitly determine the amount of
backbone amide deuterium incorporated into protein regions or segments by …

Mass spectrometry is now a well established and powerful method for analysing the
structure of biomolecules and more recently their non-covalent interactions. It is based on …

In recent years, advances in mass spectrometry have provided unprecedented knowledge of
protein expression within cells. It has become apparent that many proteins function as …

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has been
demonstrated to be a valuable tool to investigate noncovalent interactions of biomolecules …

The [Het-s] infectious element of the filamentous fungus Podospora anserina corresponds to
the prion form of the HET-s protein. HET-s (289 amino acids in length) aggregates into …

Background Hydrogen/deuterium exchange (HDX) coupled to mass spectrometry permits
analysis of structure, dynamics, and molecular interactions of proteins. HDX mass …

Abstract Hydrogen/deuterium (H/D) exchange analyzed by mass spectrometry (HXMS) is a
valuable tool for the investigation of protein conformation and dynamics. After exchange, the …

Hydrogen/deuterium exchange monitored by mass spectrometry (HDX-MS) has become an
important method to study protein dynamics in solution. Recently, electron-based …