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Spatial architecture of the immune microenvironment orchestrates tumor immunity and therapeutic response
Tumors are not only aggregates of malignant cells but also well-organized complex
ecosystems. The immunological components within tumors, termed the tumor immune …
ecosystems. The immunological components within tumors, termed the tumor immune …
Volatile compounds in human breath: critical review and meta-analysis
Volatile compounds contained in human breath reflect the inner workings of the body. A
large number of studies have been published that link individual components of breath to …
large number of studies have been published that link individual components of breath to …
NaCl enhances CD8+ T cell effector functions in cancer immunotherapy
CD8+ T cells control tumors but inevitably become dysfunctional in the tumor
microenvironment. Here, we show that sodium chloride (NaCl) counteracts T cell dysfunction …
microenvironment. Here, we show that sodium chloride (NaCl) counteracts T cell dysfunction …
Ranolazine: a potential anti-metastatic drug targeting voltage-gated sodium channels
Background Multi-faceted evidence from a range of cancers suggests strongly that de novo
expression of voltage-gated sodium channels (VGSCs) plays a significant role in driving …
expression of voltage-gated sodium channels (VGSCs) plays a significant role in driving …
Aging as a loss of morphostatic information: A developmental bioelectricity perspective
Maintaining order at the tissue level is crucial throughout the lifespan, as failure can lead to
cancer and an accumulation of molecular and cellular disorders. Perhaps, the most …
cancer and an accumulation of molecular and cellular disorders. Perhaps, the most …
[HTML][HTML] In vivo evidence for voltage-gated sodium channel expression in carcinomas and potentiation of metastasis
A wide body of evidence suggests that voltage-gated sodium channels (VGSCs) are
expressed de novo in several human carcinomas where channel activity promotes a variety …
expressed de novo in several human carcinomas where channel activity promotes a variety …
The modulatory effect of high salt on immune cells and related diseases
X Li, A Alu, Y Wei, X Wei, M Luo - Cell proliferation, 2022 - Wiley Online Library
Background The adverse effect of excessive salt intake has been recognized in decades.
Researchers have mainly focused on the association between salt intake and hypertension …
Researchers have mainly focused on the association between salt intake and hypertension …
Sodium channels and the ionic microenvironment of breast tumours
Cancers of epithelial origin such as breast, prostate, cervical, gastric, colon and lung cancer
account for a large proportion of deaths worldwide. Better treatment of metastasis, the main …
account for a large proportion of deaths worldwide. Better treatment of metastasis, the main …
Targeting ion channels for cancer treatment: current progress and future challenges
Ion channels are key regulators of cancer cell pathophysiology. They contribute to a variety
of processes such as maintenance of cellular osmolarity and membrane potential, motility …
of processes such as maintenance of cellular osmolarity and membrane potential, motility …
Anti-Tumor Activity of Hypericum perforatum L. and Hyperforin through Modulation of Inflammatory Signaling, ROS Generation and Proton Dynamics
M Menegazzi, P Masiello, M Novelli - Antioxidants, 2020 - mdpi.com
In this paper we review the mechanisms of the antitumor effects of Hypericum perforatum
L.(St. John's wort, SJW) and its main active component hyperforin (HPF). SJW extract is …
L.(St. John's wort, SJW) and its main active component hyperforin (HPF). SJW extract is …