Cannabinoids have numerous physiological effects. In the years since the molecular
identification of the G protein‐coupled receptors CB1 and CB2, the ion channel TRPV1, and …

G-protein coupled receptors (GPCRs) represent possibly the most important target class of
proteins for drug discovery. Over 30% of clinically marketed drugs are active at this receptor …

Inflammatory bowel disease (IBD) is a complex chronic inflammatory disorder of the
gastrointestinal tract. Extracellular adenosine triphosphate (eATP) produced by the …

GPR41 and GPR43 are related members of a homologous family of orphan G protein-
coupled receptors that are tandemly encoded at a single chromosomal locus in both …

G protein-coupled receptor (GPCR) signaling is the primary method eukaryotes use to
respond to specific cues in their environment. However, the relationship between stimulus …

Nicotinic acid has been used clinically for over 40 years in the treatment of dyslipidemia
producing a desirable normalization of a range of cardiovascular risk factors, including a …

Natural genetic variation can cause significant differences in gene expression, but little is
known about the polymorphisms that affect gene regulation. We analyzed regulatory …

G protein-coupled receptors (GPCRs) are a key drug target class. They account for over one-
third of current pharmaceuticals, and both drugs that inhibit and promote receptor function …

Eukaryotic cells use G-protein coupled receptors to sense diverse signals, ranging from
chemical compounds to light. Here, we exploit the remarkable sensing capacity of G-protein …

G protein-coupled receptors (GPCRs) represent the largest family of transmembrane
receptors and are responsible for transducing extracellular signals into intracellular …