A growing body of evidence suggests that inflammation, mitochondrial dysfunction and
oxidant-antioxidant imbalance may play a significant role in the development and …

This paper reviews the body of evidence that major depression is accompanied by a
decreased antioxidant status and by induction of oxidative and nitrosative (IO&NS) …

Many studies support a crucial role for oxidative & nitrosative stress (O&NS) in the
pathophysiology of unipolar and bipolar depression. These disorders are characterized inter …

Major depressive disorder (MDD) is currently the main cause of disability worldwide, but its
pathophysiology remains largely unknown, especially given its high heterogeneity in terms …

Oxidative stress is characterized by imbalanced reactive oxygen species (ROS) production
and antioxidant defenses. Two main antioxidant systems exist. The nonenzymatic system …

Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …

This paper reviews recent work on the biological underpinnings of clinical depression
emphasizing the crucial role of immunoinflammatory and oxidative and nitrosative stress …

Reactive oxygen species (ROS) are an indispensable element of cellular signal transduction
in various cell types, including bone cells. In particular, osteoclasts (OCs), cells specialized …

Microglia are activated quickly in response to external pathogens or cell debris and clear
these substances via the inflammatory response. However, excessive activation of microglia …

BACKGROUND: There is evidence that depression is accompanied by oxidative and
nitrosative stress (O&NS), as indicated by increased free radical levels, lipid peroxidation …