Cancer immunotherapy is experiencing a renaissance spearheaded by immune checkpoint
inhibitors (ICIs). This has spurred interest in 'upgrading'existing immunotherapies that …

The advances in genetics and biochemistry that have taken place over the last 10 years led
to significant advances in experimental and clinical immunology. In turn, this has led to the …

As the most powerful antigen-presenting cell type, dendritic cells (DCs) can induce potent
antigen-specific immune responses in vivo, hence becoming optimal cell population for …

Over the past decade, several immunotherapies have been approved for the treatment of
melanoma. The most prominent of these are the immune checkpoint inhibitors, which are …

The proliferation of specific lymphocytes is the central tenet of the clonal selection paradigm.
Antigen recognition by T cells triggers a series of events that produces expanded clones of …

Although the earliest—rudimentary—attempts at exploiting the immune system for cancer
therapy can be traced back to the late 18th Century, it was not until the past decade that …

Lymphocyte priming in lymph nodes (LNs) was postulated to depend on the formation of
stable T cell receptor (TCR)-specific immune synapses (ISs) with antigen (Ag)-presenting …

Effective search strategies have evolved in many biological systems, including the immune
system. T cells are key effectors of the immune response, required for clearance of …

Dendritic cells (DCs) encompass several cell subsets that collaborate to initiate and regulate
immune responses. Proper DC localization determines their function and requires the tightly …

Viruses naturally engage innate immunity, induce antigen presentation, and mediate CD8 T
cell priming against foreign antigens. Polioviruses can provide a context optimal for …