This chapter reviews the neurological phenotype of Down syndrome (DS) in early
development, childhood, and aging. Neuroanatomic abnormalities in DS are manifested as …

Recent studies indicate that the dual‐specificity tyrosine phosphorylation‐regulated kinase
1A (DYRK1A) gene, which is located on chromosome 21q22. 2 and is overexpressed in …

Down's syndrome is a genetic disorder that can lead to mental retardation of varying
degrees. How this chromosomal abnormality causes mental retardation remains an open …

Of the recent advances in education‐related research in Down syndrome, the
characterization of the Down syndrome behavioral phenotype has become a potentially …

Down syndrome (DS) is the leading cause of genetically-defined intellectual disability and
congenital birth defects. Despite being one of the first genetic diseases identified, only …

Abstract Most individuals with Down Syndrome (DS) show an early‐onset of Alzheimer's
disease (AD), which potentially results from the presence of an extra copy of a segment of …

Down syndrome is the most common genetic developmental disorder in humans and is
caused by partial or complete triplication of human chromosome 21 (trisomy 21). It is a …

purpose. Infants and children with Down syndrome show reduced visual acuity and contrast
sensitivity when tested with conventional behavioral techniques. These results may reflect …

BACKGROUND. In the immature develo** fetal brain, amino acids (such as γ-
aminobutyric acid, and taurine) and monoamines (serotonin, noradrenaline, and dopamine) …

Mesial temporal lobe epilepsy (MTLE), the most common form of epilepsy, is characterised
by cytoarchitectural abnormalities including neuronal cell loss and reactive gliosis in …