The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Apoptosis, a type of genetically controlled cell death, is a fundamental cellular mechanism
utilized by multicellular organisms for disposal of cells that are no longer needed or …

Voltage-gated potassium channel Kv1. 3 is an integral membrane protein, which is
selectively permeable for potassium ions and is activated upon a change of membrane …

Pharmacological targeting of mitochondrial ion channels is emerging as a promising
approach to eliminate cancer cells; as most of these channels are differentially expressed …

This article provides an overview of the various research approaches we have explored in
recent years to improve metal-based agents for cancer or infection treatments. Although …

Since the discovery of the participation of various ion channels in the regulation of cell
proliferation and programmed cell death two decades ago, the field exploring ion channel …

Among different strategies to develop novel therapies, drug repositioning (aka repurposing)
aims at identifying new uses of an already approved or investigational drug. This approach …

Introduction: The voltage-dependent potassium channel Kv1. 3 is mainly present in the
nervous and immune systems. In leukocytes, Kv1. 3 fine-tunes the activation and …

In the battle against cancer cells, therapeutic modalities are drastically limited by intrinsic or
acquired drug resistance. Resistance to therapy is not only common, but expected: if …

Background: Platinum-based drugs such as Cisplatin are commonly employed for cancer
treatment. Despite an initial therapeutic response, Cisplatin treatment often results in the …