[HTML][HTML] Polymer-and lipid-based nanocarriers for ocular drug delivery: current status and future perspectives
H Han, S Li, M Xu, Y Zhong, W Fan, J Xu, T Zhou… - Advanced Drug Delivery …, 2023 - Elsevier
Ocular diseases seriously affect patients' vision and life quality, with a global morbidity of
over 43 million blindness. However, efficient drug delivery to treat ocular diseases …
over 43 million blindness. However, efficient drug delivery to treat ocular diseases …
Structure and function of cationic and ionizable lipids for nucleic acid delivery
Hereditary genetic diseases, cancer, and infectious diseases are affecting global health and
become major health issues, but the treatment development remains challenging. Gene …
become major health issues, but the treatment development remains challenging. Gene …
A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing
Delivery technologies for the CRISPR-Cas9 (CRISPR, clustered regularly interspaced short
palindromic repeats) gene editing system often require viral vectors, which pose safety …
palindromic repeats) gene editing system often require viral vectors, which pose safety …
Systemic delivery of tumor-targeting siRNA nanoparticles against an oncogenic LncRNA facilitates effective triple-negative breast cancer therapy
Long noncoding RNAs (lncRNAs), by virtue of their versatility and multilevel gene regulation,
have emerged as attractive pharmacological targets for treating heterogeneous and …
have emerged as attractive pharmacological targets for treating heterogeneous and …
Gene therapy for inherited retinal disease: Long-term durability of effect
The recent approval of voretigene neparvovec (Luxturna®) for patients with biallelic RPE65
mutation-associated inherited retinal dystrophy with viable retinal cells represents an …
mutation-associated inherited retinal dystrophy with viable retinal cells represents an …
[HTML][HTML] Optimizing synthetic nucleic acid and protein nanocarriers: The chemical evolution approach
F Freitag, E Wagner - Advanced drug delivery reviews, 2021 - Elsevier
Optimizing synthetic nanocarriers is like searching for a needle in a haystack. How to find
the most suitable carrier for intracellular delivery of a specified macromolecular nanoagent …
the most suitable carrier for intracellular delivery of a specified macromolecular nanoagent …
A pH-responsive silica–metal–organic framework hybrid nanoparticle for the delivery of hydrophilic drugs, nucleic acids, and CRISPR-Cas9 genome-editing …
Efficient delivery of hydrophilic drugs, nucleic acids, proteins, and any combination thereof is
essential for various biomedical applications. Herein, we report a straightforward, yet …
essential for various biomedical applications. Herein, we report a straightforward, yet …
Ocular drug delivery: advancements and innovations
Ocular drug delivery has been significantly advanced for not only pharmaceutical
compounds, such as steroids, nonsteroidal anti-inflammatory drugs, immune modulators …
compounds, such as steroids, nonsteroidal anti-inflammatory drugs, immune modulators …
Effective gene therapy of Stargardt disease with PEG-ECO/pGRK1-ABCA4-S/MAR nanoparticles
Stargardt disease (STGD) is the most common form of inherited retinal genetic disorders and
is often caused by mutations in ABCA4. Gene therapy has the promise to effectively treat …
is often caused by mutations in ABCA4. Gene therapy has the promise to effectively treat …
[HTML][HTML] What's new in ocular drug delivery: advances in suprachoroidal injection since 2023
Despite significant advancements in ocular drug delivery, challenges persist in treating
posterior segment diseases like macular edema (ME) and age-related macular …
posterior segment diseases like macular edema (ME) and age-related macular …