From bacteria to mammalian cells, damaged DNA is sensed and targeted by DNA repair
pathways. In eukaryotes, kinases play a central role in coordinating the DNA damage …

Significance: The detrimental effects of ionizing radiation (IR) involve a highly orchestrated
series of events that are amplified by endogenous signaling and culminating in oxidative …

PINK1 kinase activates the E3 ubiquitin ligase Parkin to induce selective autophagy of
damaged mitochondria. However, it has been unclear how PINK1 activates and recruits …

In order to maintain genomic stability, cells have developed sophisticated signalling
pathways to enable DNA damage or DNA replication stress to be resolved. Key mediators of …

We have previously reported that the Parkinson's disease-associated kinase PINK1 (PTEN-
induced putative kinase 1) is activated by mitochondrial depolarization and stimulates the …

Poor survival rates of patients with tumors arising from or disseminating into the brain are
attributed to an inability to excise all tumor tissue (if operable), a lack of blood-brain barrier …

Damage to our genetic material is an ongoing threat to both our ability to faithfully transmit
genetic information to our offspring as well as our own survival. To respond to these threats …

Cancer‐associated fibroblasts (CAFs) as a predominant cell component in the tumour
microenvironment (TME) play an essential role in tumour progression. Our earlier studies …

Execution of the DNA damage response (DDR) relies upon a dynamic array of protein
modifications. Using quantitative proteomics, we have globally profiled ubiquitination …

Summary N 6-methyladenosine (m 6 A) is the most abundant mRNA modification and is
installed by the METTL3-METTL14-WTAP methyltransferase complex. Although the …