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Advances in the structure, mechanism and targeting of chemoresistance-linked ABC transporters
Cancer cells frequently display intrinsic or acquired resistance to chemically diverse
anticancer drugs, limiting therapeutic success. Among the main mechanisms of this …
anticancer drugs, limiting therapeutic success. Among the main mechanisms of this …
Chemical molecular‐based approach to overcome multidrug resistance in cancer by targeting P‐glycoprotein (P‐gp)
Multidrug resistance (MDR) remains one of the major impediments for efficacious cancer
chemotherapy. Increased efflux of multiple chemotherapeutic drugs by transmembrane ATP …
chemotherapy. Increased efflux of multiple chemotherapeutic drugs by transmembrane ATP …
Multidrug resistance proteins (MRPs): Structure, function and the overcoming of cancer multidrug resistance
ATP-binding cassette (ABC) transporters mediate the ATP-driven translocation of structurally
and mechanistically distinct substrates against steep concentration gradients. Among the …
and mechanistically distinct substrates against steep concentration gradients. Among the …
ATP‐binding cassette (ABC) transporters in cancer: A review of recent updates
The ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …
Structural and functional aspects of P-glycoprotein and its inhibitors
Abstract P-glycoprotein (P-gp) is a member of ATP-binding cassette (ABC) superfamily
which extrudes chemotherapeutic agents out of the cell. Suppression of this efflux activity …
which extrudes chemotherapeutic agents out of the cell. Suppression of this efflux activity …
Antibody-Free Fluorine-Assisted Metabolic Sequencing of RNA N4-Acetylcytidine
N 4-Acetylcytidine (ac4C) has been found to affect a variety of cellular and biological
processes. For a mechanistic understanding of the roles of ac4C in biology and disease, we …
processes. For a mechanistic understanding of the roles of ac4C in biology and disease, we …
The role of ABCC10/MRP7 in anti-cancer drug resistance and beyond
Abstract Multidrug resistance protein 7 (MRP7), also known as ATP-binding cassette (ABC)
transporter subfamily C10 (ABCC10), is an ABC transporter that was first identified in 2001 …
transporter subfamily C10 (ABCC10), is an ABC transporter that was first identified in 2001 …
Discovery of new 4-indolyl quinazoline derivatives as highly potent and orally bioavailable P-glycoprotein inhibitors
S Yuan, B Wang, QQ Dai, XN Zhang… - Journal of Medicinal …, 2021 - ACS Publications
The major drawbacks of P-glycoprotein (P-gp) inhibitors at the clinical stage make the
development of new P-gp inhibitors challenging and desirable. In this study, we reported our …
development of new P-gp inhibitors challenging and desirable. In this study, we reported our …
Evaluation of the FDA-approved kinase inhibitors to uncover the potential repurposing candidates targeting ABC transporters in multidrug-resistant cancer cells: an in …
Multiple drug resistance (MDR) is characterized by the resistance of cancer cells to a broad
spectrum of anticancer drugs. The main mechanism underlying the MDR phenotype is the …
spectrum of anticancer drugs. The main mechanism underlying the MDR phenotype is the …
Lysine-specific demethylase 1 promises to be a novel target in cancer drug resistance: therapeutic implications
Chemotherapy, targeted therapy, and immunotherapy are effective against most tumors, but
drug resistance remains a barrier to successful treatment. Lysine-specific demethylase 1 …
drug resistance remains a barrier to successful treatment. Lysine-specific demethylase 1 …