Testosterone replacement therapy and cardiovascular risk

T Gagliano-Jucá, S Basaria - Nature Reviews Cardiology, 2019 - nature.com
Testosterone is the main male sex hormone and is essential for the maintenance of male
secondary sexual characteristics and fertility. Androgen deficiency in young men owing to …

Dihydrotestosterone: biochemistry, physiology, and clinical implications of elevated blood levels

RS Swerdloff, RE Dudley, ST Page, C Wang… - Endocrine …, 2017 - academic.oup.com
Benefits associated with lowered serum DHT levels after 5 α-reductase inhibitor (5AR-I)
therapy in men have contributed to a misconception that circulating DHT levels are an …

Evaluation and management of testosterone deficiency: AUA guideline

JP Mulhall, LW Trost, RE Brannigan, EG Kurtz… - The Journal of …, 2018 - auajournals.org
Purpose: There has been a marked increase in testosterone prescriptions in the past
decade resulting in a growing need to give practicing clinicians proper guidance on the …

Testosterone treatment and risk of venous thromboembolism: population based case-control study

C Martinez, S Suissa, S Rietbrock, A Katholing… - bmj, 2016 - bmj.com
Objective To determine the risk of venous thromboembolism associated with use of
testosterone treatment in men, focusing particularly on the timing of the risk. Design …

Aging and the male reproductive system

JM Kaufman, B Lapauw, A Mahmoud… - Endocrine …, 2019 - academic.oup.com
This narrative review presents an overview of current knowledge on fertility and reproductive
hormone changes in aging men, the factors driving and modulating these changes, their …

Association of testosterone therapy with risk of venous thromboembolism among men with and without hypogonadism

RF Walker, NA Zakai, RF MacLehose… - JAMA internal …, 2020 - jamanetwork.com
Importance Testosterone therapy is increasingly prescribed in patients without a diagnosis
of hypogonadism. This therapy may be associated with increased risk of venous …

Testosterone and cardiovascular health

A Elagizi, TS Köhler, CJ Lavie - Mayo Clinic Proceedings, 2018 - Elsevier
There is an ongoing debate in the medical community regarding the effects of testosterone
on cardiovascular (CV) health. For decades, there has been conflicting evidence regarding …

Testosterone replacement therapy: for whom, when and how?

CP Tsametis, AM Isidori - Metabolism, 2018 - Elsevier
The finding of low circulating testosterone level in men is relatively frequent. The symptoms
of hypogonadism are very frequent in the aging men. However, the diagnosis of …

Sex‐specific and hormone‐related differences in vascular remodelling in atherosclerosis

A Yerly, EPC van der Vorst… - European Journal of …, 2023 - Wiley Online Library
Atherosclerosis, a lipid‐driven inflammatory disease, is the main underlying cause of
cardiovascular diseases (CVDs) both in men and women. Sex‐related dimorphisms …

Testosterone therapy and venous thromboembolism: a systematic review and meta-analysis

DE Houghton, M Alsawas, P Barrioneuvo, M Tello… - Thrombosis research, 2018 - Elsevier
Background Testosterone prescribing for men has dramatically increased, and there have
been concerns about inappropriate use and adverse events. While regulatory bodies have …