miRNAs: potential as biomarkers and therapeutic targets for cancer

A Chakrabortty, DJ Patton, BF Smith, P Agarwal - Genes, 2023 - mdpi.com
MicroRNAs (miRNAs) are single-stranded, non-coding RNA molecules that regulate gene
expression post-transcriptionally by binding to messenger RNAs. miRNAs are important …

Circulating microRNAs in cancer: potential and challenge

M Cui, H Wang, X Yao, D Zhang, Y **e, R Cui… - Frontiers in …, 2019 - frontiersin.org
MicroRNAs (miRNAs) are endogenous non-coding small RNA molecules that can be
secreted into the circulation and exist in remarkably stable forms. Like intercellular miRNAs …

Liquid biopsies come of age: towards implementation of circulating tumour DNA

JCM Wan, C Massie, J Garcia-Corbacho… - Nature Reviews …, 2017 - nature.com
Improvements in genomic and molecular methods are expanding the range of potential
applications for circulating tumour DNA (ctDNA), both in a research setting and as a'liquid …

Circulating microRNAs as potential cancer biomarkers: the advantage and disadvantage

H Wang, R Peng, J Wang, Z Qin, L Xue - Clinical epigenetics, 2018 - Springer
MicroRNAs are endogenous single-stranded non-coding small RNA molecules that can be
secreted into the circulation and exist stably. They usually exhibit aberrant expression under …

The promising role of miR-21 as a cancer biomarker and its importance in RNA-based therapeutics

D Bautista-Sánchez, C Arriaga-Canon… - … therapy Nucleic acids, 2020 - cell.com
MicroRNAs are small noncoding transcripts that posttranscriptionally regulate gene
expression via base-pairing complementarity. Their role in cancer can be related to tumor …

MicroRNAs in cancer: biomarkers, functions and therapy

J Hayes, PP Peruzzi, S Lawler - Trends in molecular medicine, 2014 - cell.com
The emergence of microRNAs has been one of the defining developments in cancer biology
over the past decade, and the explosion of knowledge in this area has brought forward new …

MicroRNA and cancer–a brief overview

M Acunzo, G Romano, D Wernicke… - Advances in biological …, 2015 - Elsevier
MicroRNAs (miRNAs) are short non-coding RNAs with a length of∼ 22 nucleotides,
involved in posttranscriptional regulation of gene expression. Until now, over 2588 miRNAs …

Circulating exosomal microRNAs as biomarkers of colon cancer

H Ogata-Kawata, M Izumiya, D Kurioka, Y Honma… - PloS one, 2014 - journals.plos.org
Purpose Exosomal microRNAs (miRNAs) have been attracting major interest as potential
diagnostic biomarkers of cancer. The aim of this study was to characterize the miRNA …

MicroRNA profiling: approaches and considerations

CC Pritchard, HH Cheng, M Tewari - Nature Reviews Genetics, 2012 - nature.com
MicroRNAs (miRNAs) are small RNAs that post-transcriptionally regulate the expression of
thousands of genes in a broad range of organisms in both normal physiological contexts …

Tumor origin detection with tissue-specific miRNA and DNA methylation markers

W Tang, S Wan, Z Yang, AE Teschendorff… - Bioinformatics, 2018 - academic.oup.com
Motivation A clear identification of the primary site of tumor is of great importance to the next
targeted site-specific treatments and could efficiently improve patient's overall survival. Even …