This scientific paper presents an overview of continuous solution crystallization in the
pharmaceutical industry. Since the specific knowledge spectrum of precipitation is very …

Continuous crystallization has gained interest in the pharmaceutical sector as part of the
drive toward the transition from exclusive batch manufacturing to integrated continuous …

Process alternatives for continuous crystallization, ie, cascades of mixed suspension, mixed
product removal crystallizers (MSMPRCs) and plug flow crystallizers (PFCs), as well as …

This work details the estimation of the secondary nucleation kinetics of paracetamol in
ethanol solutions for cooling crystallisation processes, by means of isothermal under …

Controlling crystal size distributions is critical to ensure the quality of products and
operational efficiency for downstream processing. In batch cooling crystallization …

Prediction and control of the product properties in crystallization processes are practical
challenges in the pharmaceutical industry. Effective crystallization process design and …

Both primary and secondary nucleation rates are considered in a model developed for
unseeded batch crystallization. A carefully designed strategy was employed to minimize the …

The analysis, development, and implementation of novel complex industrial crystallization
processes requires kinetic knowledge of not only crystal growth and nucleation but also …

In this article, we report, for the first time, a reactive seeded cooling crystallization of
paracetamol successfully performed in a continuous oscillatory baffled reactor (COBR). The …

This work presents a mathematical model that describes growth, homogeneous nucleation,
and secondary nucleation that is caused by interparticle interactions between seed crystals …