Cytokines of the IL-12 family show structural similarities but have distinct functions in the
immune system. Prominent members of this cytokine family are the pro-inflammatory …

Immune deficiency of diverse etiology, including human immunodeficiency virus (HIV),
antineoplastic agents, immunosuppressive agents used in solid organ recipients …

Introduction It is well established that starting antiretroviral therapy (ART) increases a
patient's life expectancy among HIV-positive individuals. Considering the HIV pandemic, the …

As a key element in the T-helper 17 (Th17) cell-mediated inflammatory process, interleukin-
23 receptor (IL-23R) may play a crucial role in the pathogenesis of atherosclerosis. Single …

Cytokines control immune related events and are critically involved in a plethora of patho-
physiological processes including autoimmunity and cancer development. In rare cases …

Background Severe tuberculosis constitutes a significant menace to human safety and well-
being, with a considerable mortality rate. The severity of tuberculosis can be impacted by …

Schistosomiasis is a neglected parasitic disease linked to water, posing a global public
health concern with a significant burden in sub-Saharan Africa. It is transmitted by …

Background Improved understanding of the molecular mechanisms involved in pediatric
severe malarial anemia (SMA) pathogenesis is a crucial step in the design of novel …

In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe
malarial anemia [SMA, hemoglobin (Hb)< 6.0 g/dL, with any density parasitemia] is the most …

Background In areas where HIV and intestinal schistosomiasis are highly endemic, co-
infections of the two diseases in a single human host are frequent. Evidence in adult …