Piano stool Ru (II)-arene complexes having three monodentate legs: A comprehensive review on their development as anticancer therapeutics over the past decade
The popularity of RAPTA-C in in vivo studies has steered the way for complexes of the type
[Ru (η 6-arene)(X)(Y)(Z)] n+ (where X, Y and Z are monodentate ligands) to be developed …
[Ru (η 6-arene)(X)(Y)(Z)] n+ (where X, Y and Z are monodentate ligands) to be developed …
Recent progress in the development of organometallics for the treatment of cancer
BS Murray, PJ Dyson - Current opinion in chemical biology, 2020 - Elsevier
From their early successes in medicine, organometallic compounds continue to attract
interest as potential chemotherapeutics to treat a range of diseases. Here, we show from …
interest as potential chemotherapeutics to treat a range of diseases. Here, we show from …
Histone divergence in trypanosomes results in unique alterations to nucleosome structure
G Deák, H Wapenaar, G Sandoval, R Chen… - Nucleic Acids …, 2023 - academic.oup.com
Eukaryotes have a multitude of diverse mechanisms for organising and using their
genomes, but the histones that make up chromatin are highly conserved. Unusually …
genomes, but the histones that make up chromatin are highly conserved. Unusually …
Recent considerations in the application of RAPTA‐C for cancer treatment and perspectives for its combination with immunotherapies
M Rausch, PJ Dyson… - Advanced …, 2019 - Wiley Online Library
The organometallic ruthenium (II)[Ru (arene) Cl2PTA] PTA‐1, 3, 5‐triaza‐7‐
phosphaadamantane compound, RAPTA‐C, represents an innovative anti‐cancer …
phosphaadamantane compound, RAPTA‐C, represents an innovative anti‐cancer …
Near-atomic resolution structures of interdigitated nucleosome fibres
Chromosome structure at the multi-nucleosomal level has remained ambiguous in spite of
its central role in epigenetic regulation and genome dynamics. Recent investigations of …
its central role in epigenetic regulation and genome dynamics. Recent investigations of …
Multinuclear biologically active Ru, Rh, Os and Ir arene complexes
P Štarha - Coordination Chemistry Reviews, 2021 - Elsevier
The development of multinuclear homometallic biologically active complexes is attractive for
modern bioinorganic chemistry, because this concept offers a multiplication of the …
modern bioinorganic chemistry, because this concept offers a multiplication of the …
Binding mechanisms of half-sandwich Rh (III) and Ru (II) arene complexes on human serum albumin: A comparative study
Various half-sandwich ruthenium (II) arene complexes and rhodium (III) arene complexes
have been intensively investigated due to their prominent anticancer activity. The interaction …
have been intensively investigated due to their prominent anticancer activity. The interaction …
Epstein-Barr virus protein BKRF4 restricts nucleosome assembly to suppress host antiviral responses
J Chen, Z Lu, W Gong, X **ao, X Feng… - Proceedings of the …, 2022 - National Acad Sciences
Inhibition of host DNA damage response (DDR) is a common mechanism used by viruses to
manipulate host cellular machinery and orchestrate viral life cycles. Epstein-Barr virus …
manipulate host cellular machinery and orchestrate viral life cycles. Epstein-Barr virus …
Anticancer organorhodium and-iridium complexes with low toxicity in vivo but high potency in vitro: DNA damage, reactive oxygen species formation, and haemolytic …
Redox-modulating anticancer drugs allow the exploitation of altered redox biology observed
in many cancer cells. We discovered dinuclear RhIII (Cp*) and IrIII (Cp*) complexes that …
in many cancer cells. We discovered dinuclear RhIII (Cp*) and IrIII (Cp*) complexes that …
Dichloro Ru(II)-p-cymene-1,3,5-triaza-7-phosphaadamantane (RAPTA-C): A Case Study
The use of organometallic compounds to treat various phenotypes of cancer has attracted
increased interest in recent decades. Organometallic compounds, which are transitional …
increased interest in recent decades. Organometallic compounds, which are transitional …