Emerging roles for platelets as immune and inflammatory cells
CN Morrell, AA Aggrey, LM Chapman… - Blood, The Journal of …, 2014 - ashpublications.org
Despite their small size and anucleate status, platelets have diverse roles in vascular
biology. Not only are platelets the cellular mediator of thrombosis, but platelets are also …
biology. Not only are platelets the cellular mediator of thrombosis, but platelets are also …
Inflammatory chemokines in atherosclerosis
Atherosclerosis is a long-term, chronic inflammatory disease of the vessel wall leading to the
formation of occlusive or rupture-prone lesions in large arteries. Complications of …
formation of occlusive or rupture-prone lesions in large arteries. Complications of …
Neutrophils responsive to endogenous IFN-β regulate tumor angiogenesis and growth in a mouse tumor model
J Jablonska, S Leschner, K Westphal… - The Journal of …, 2010 - Am Soc Clin Investig
Angiogenesis is a hallmark of malignant neoplasias, as the formation of new blood vessels
is required for tumors to acquire oxygen and nutrients essential for their continued growth …
is required for tumors to acquire oxygen and nutrients essential for their continued growth …
Platelets guide leukocytes to their sites of extravasation
G Zuchtriegel, B Uhl, D Puhr-Westerheide… - PLoS …, 2016 - journals.plos.org
Effective immune responses require the directed migration of leukocytes from the
vasculature to the site of injury or infection. How immune cells “find” their site of …
vasculature to the site of injury or infection. How immune cells “find” their site of …
Chemokines modulate the tumour microenvironment in pituitary neuroendocrine tumours
P Marques, S Barry, E Carlsen, D Collier… - Acta neuropathologica …, 2019 - Springer
Non-tumoural cells within the tumour microenvironment (TME) influence tumour
proliferation, invasiveness and angiogenesis. Little is known about TME in pituitary …
proliferation, invasiveness and angiogenesis. Little is known about TME in pituitary …
Small extracellular vesicles secreted by nigrostriatal astrocytes rescue cell death and preserve mitochondrial function in Parkinson's disease
Extracellular vesicles (EVs) are emerging as powerful players in cell‐to‐cell communication
both in healthy and diseased brain. In Parkinson's disease (PD)—characterized by selective …
both in healthy and diseased brain. In Parkinson's disease (PD)—characterized by selective …
Crossing the vascular wall: common and unique mechanisms exploited by different leukocyte subsets during extravasation
Leukocyte extravasation is one of the essential and first steps during the initiation of
inflammation. Therefore, a better understanding of the key molecules that regulate this …
inflammation. Therefore, a better understanding of the key molecules that regulate this …
Molecular dialogs between the ischemic brain and the peripheral immune system: dualistic roles in injury and repair
Immune and inflammatory responses actively modulate the pathophysiological processes of
acute brain injuries such as stroke. Soon after the onset of stroke, signals such as brain …
acute brain injuries such as stroke. Soon after the onset of stroke, signals such as brain …
Progesterone receptor serves the ovary as a trigger of ovulation and a terminator of inflammation
Ovulation is triggered by the gonadotropin surge that induces the expression of two key
genes, progesterone receptor (Pgr) and prostaglandin-endoperoxide synthase 2 (Ptgs2), in …
genes, progesterone receptor (Pgr) and prostaglandin-endoperoxide synthase 2 (Ptgs2), in …
Endothelial inflammation and neutrophil transmigration are modulated by extracellular matrix composition in an inflammation-on-a-chip model
RB Riddle, K Jennbacken, KM Hansson, MT Harper - Scientific Reports, 2022 - nature.com
Inflammatory diseases are often characterised by excessive neutrophil infiltration from the
blood stream to the site of inflammation, which damages healthy tissue and prevents …
blood stream to the site of inflammation, which damages healthy tissue and prevents …