MicroRNAs (miRNAs) are small RNAs that post-transcriptionally regulate the expression of
thousands of genes in a broad range of organisms in both normal physiological contexts …

Many studies have highlighted the role that microRNAs have in physiological processes and
how their deregulation can lead to cancer. More recently, it has been proposed that the …

Abstract microRNAs (miRNAs) are a large class of small non-coding RNAs which post-
transcriptionally regulate the expression of a large fraction of all animal genes and are …

This review will summarise the recent discoveries and current state of research on short
noncoding RNAs derived from tRNAs—known as tRNA-derived fragments (tRFs). It will …

Psoriasis is a chronic and complex inflammatory skin disease with lesions displaying
dramatically altered mRNA expression profiles. However, much less is known about the …

Canonical microRNA biogenesis requires the Microprocessor components, Drosha and
DGCR8, to generate precursor-miRNA, and Dicer to form mature miRNA. The …

Recent advances in the understanding of the genetics of type 2 diabetes (T2D) susceptibility
have focused attention on the regulation of transcriptional activity within the pancreatic beta …

MicroRNA‐378a (miR‐378a, previously known as miR‐378) is one of the small noncoding
RNA molecules able to regulate gene expression at posttranscriptional level. Its two mature …

Synonymous mutations, which do not alter the protein sequence, have been shown to affect
protein function [Sauna ZE, Kimchi-Sarfaty C (2011) Nat Rev Genet 12 (10): 683–691] …

To identify microRNAs potentially involved in melanomagenesis, we compared microRNA
expression profiles between melanoma cell lines and cultured melanocytes. The most …