Since its inception, the amyloid cascade hypothesis has dominated the field of Alzheimer's
disease (AD) research and has provided the intellectual framework for therapeutic …

Levels of amyloid-beta monomer and deposited amyloid-beta in the Alzheimer's disease
brain are orders of magnitude greater than soluble amyloid-beta oligomer levels. Monomeric …

The aberrant assembly of peptides and proteins into fibrillar aggregates proceeds through
oligomeric intermediates that are thought to be the primary pathogenic species in many …

This chapter outlines protocols that produce homogenous preparations of oligomeric and
fibrillar amyloid-β peptide (Aβ). While there are several isoforms of this peptide, the 42 …

Amyloidoses are diseases characterized by abnormal protein folding and self-assembly, for
which no cure is available. Inhibition or modulation of abnormal protein self-assembly …

The pathogenesis of Alzheimer's disease is characterized by the aggregation and fibrillation
of amyloid peptides Aβ1–40 and Aβ1–42 into amyloid plaques. Despite strong potential …

Molecular tweezers represent the first class of artificial receptor molecules that have made
the way from a supramolecular host to a drug candidate with promising results in animal …

We have previously reported anti-amyloidogenic effects of leptin using in vitro and in vivo
models and, more recently, demonstrated the ability of leptin to reduce tau phosphorylation …

Recent studies have implicated non-fibrillar oligomers of the amyloid β (Aβ) peptide as the
primary toxic species in Alzheimer's disease. Detailed structural and kinetic characterization …

The presence of the cellular prion protein (PrP C) on the cell surface is critical for the
neurotoxicity of prions. Although several biological activities have been attributed to PrP C, a …