Diabetic kidney disease (DKD) is the primary cause of chronic kidney disease that inevitably
progress to end-stage kidney disease. Intervention strategies such as blood glucose control …

Current criteria for the diagnosis of CKD in adults include persistent signs of kidney damage,
such as increased urine albumin-to-creatinine ratio or a GFR below the threshold of 60 …

Answering the question as to why we age is tantamount to answering the question of what is
life itself. There are countless theories as to why and how we age, but, until recently, the very …

Sex and gender differences are of fundamental importance in most diseases, including
chronic kidney disease (CKD). Men and women with CKD differ with regard to the …

As human life expectancy keeps increasing, ageing populations present a growing
challenge for clinical practices. Human ageing is associated with molecular, structural, and …

Inflammation plays a pivotal role in pathophysiological processes of kidney diseases.
Macroautophagy/autophagy plays multiple roles in inflammatory responses, and the …

Background: Although the number of patients reaching end-stage kidney disease without a
biopsy-proven diagnosis is increasing, the utility of renal biopsy is still an object of debate …

General cognitive function is substantially heritable across the human life course from
adolescence to old age. We investigated the genetic contribution to variation in this …

Background. The utility of renal biopsy in patients with diabetes is highly debated. Diabetics
with rapidly worsening renal disease are often 'clinically'labelled as having diabetic …

Little is known about the molecular changes that take place in the kidney during the aging
process. In order to better understand these changes, we measured mRNA and protein …