Treatment strategies for clear cell renal cell carcinoma: Past, present and future

J Yang, K Wang, Z Yang - Frontiers in oncology, 2023 - frontiersin.org
Clear cell renal cell carcinoma (ccRCC) is the most prevalent histological subtype of kidney
cancer, which is prone to metastasis, recurrence, and resistance to radiotherapy and …

Evolution of the HIF targeted therapy in clear cell renal cell carcinoma

B Golijanin, K Malshy, S Khaleel, G Lagos… - Cancer Treatment …, 2023 - Elsevier
Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer, affecting
hundreds of thousands of people worldwide and can affect people of any age. The …

[PDF][PDF] Pericyte phenotype switching alleviates immunosuppression and sensitizes vascularized tumors to immunotherapy in preclinical models

ZJ Li, B He, A Domenichini, J Satiaputra… - Journal of Clinical …, 2024 - jci.org
T cell–based immunotherapies are a promising therapeutic approach for multiple
malignancies, but their efficacy is limited by tumor hypoxia arising from dysfunctional blood …

[HTML][HTML] Degradable hydrogel for sustained localized delivery of anti-tumor drugs

T Lessmann, SA Jones, T Voigt, S Weisbrod… - Journal of …, 2023 - Elsevier
Disadvantages of systemically administered immunomodulatory anti-tumor therapies
include poor efficacy and high toxicity. Direct intratumoral injection of a drug is often …

[HTML][HTML] Thymic epithelial tumor and Immune System: the role of Immunotherapy

M Perrino, N Cordua, F De Vincenzo, F Borea… - Cancers, 2023 - mdpi.com
Simple Summary Similarly to other solid malignancies, there is a growing interest in testing
immune checkpoint inhibitors (ICIs) for thymic epithelial tumors (TETs). However, the thymus …

Use of circular RNAs in diagnosis, prognosis and therapeutics of renal cell carcinoma

R Osca-Verdegal, J Beltrán-García, JL Górriz… - Frontiers in Cell and …, 2022 - frontiersin.org
Renal cell carcinoma is the most common type of kidney cancer, representing 90% of kidney
cancer diagnoses, and the deadliest urological cancer. While the incidence and mortality …

The current progress and future options of multiple therapy and potential biomarkers for muscle-invasive bladder cancer

Y Shi, BJ Mathis, Y He, X Yang - Biomedicines, 2023 - mdpi.com
Bladder cancer is a common disease in men and the elderly. Current treatment paradigms
include radical resection of the bladder and lymph nodes or transurethral resection, both …

Overexpression of complement C5a indicates poor survival and therapeutic response in metastatic renal cell carcinoma

C Yang, F Yang, X Chen, Y Li, X Hu… - … Journal of Biological …, 2023 - journals.sagepub.com
Introduction Complement C5a is an important component of the innate immune system. An
increasing number of reports have revealed the relevance of C5a in tumor progression; …

Comprehensive assessments of immuno‐oncology drug‐based combination therapies as first‐line treatment for advanced renal cell carcinoma

K Harada, H Miyake, J Furukawa… - … Journal of Urology, 2022 - Wiley Online Library
Over the last decade, there have been substantial progress in the field of systemic therapy
for advanced renal cell carcinoma. Through the transition from treatment with cytokines to …

Rationale for immune checkpoint inhibitors plus targeted therapy for advanced renal cell carcinoma

S Yang, X Yang, Z Hou, L Zhu, Z Yao, Y Zhang, Y Chen… - Heliyon, 2024 - cell.com
Renal cell carcinoma (RCC) is a frequent urological malignancy characterized by a high rate
of metastasis and lethality. The treatment strategy for advanced RCC has moved through …