OBJECTIVE: The authors review the mechanisms and establish the risk of torsade de
pointes and sudden death with antipsychotic drugs. METHOD: They present a review of …

Schizophrenia is a chronic and debilitating neuropsychiatric disorder affecting
approximately 1% of the world's population. This disease is associated with considerable …

Background Users of typical antipsychotic drugs have an increased risk of serious
ventricular arrhythmias and sudden cardiac death. However, less is known regarding the …

Objective: To demonstrate the feasibility of a placebo-controlled trial of antipsychotics for
delirium in the intensive care unit and to test the hypothesis that antipsychotics would …

Sudden unexpected deaths have been reported with antipsychotic use since the early
1960s. In some cases the antipsychotic may be unrelated to death, but in others it appears to …

These updated guidelines from the British Association for Psychopharmacology replace the
original version published in 2011. They address the scope and targets of pharmacological …

Cardiovascular toxicity remains a major cause of concern during preclinical and clinical
development as well as contributing to post-approval withdrawal of medicines. This issue is …

Background An intramuscular (IM) formulation of olanzapine has been developed because
there are no rapid-acting IM atypical antipsychotic drugs currently available in the United …

Introduction: Antipsychotic polypharmacy (APP), the concomitant use of≥ 2 antipsychotics,
is common in clinical practice. Prior reviews have focused on the efficacy of APP, but no …

Background: Clozapine is an antipsychotic medication associated with a lower suicide rate
compared with other antipsychotic agents. Clozapine is used specifically in patients for …