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3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs
AS Nunes, AS Barros, EC Costa… - Biotechnology and …, 2019 - Wiley Online Library
Three‐dimensional cell culture models, such as spheroids, can be used in the process of the
development of new anticancer agents because they are able to closely mimic the main …
development of new anticancer agents because they are able to closely mimic the main …
Tumor‐derived spheroids: relevance to cancer stem cells and clinical applications
T Ishiguro, H Ohata, A Sato, K Yamawaki… - Cancer …, 2017 - Wiley Online Library
Recently, many types of in vitro 3‐D culture systems have been developed to recapitulate
the in vivo growth conditions of cancer. The cancer 3‐D culture methods aim to preserve the …
the in vivo growth conditions of cancer. The cancer 3‐D culture methods aim to preserve the …
Promising applications of tumor spheroids and organoids for personalized medicine
Simple Summary Presently, the investigation of the tumor is carried out using different
models. One of the promising areas is the creation of 3D tumor models, such as spheroids …
models. One of the promising areas is the creation of 3D tumor models, such as spheroids …
Spheroids formation on non‐adhesive surfaces by liquid overlay technique: Considerations and practical approaches
Scalable and reproducible production of 3D cellular spheroids is highly demanded, by
pharmaceutical companies, for drug screening purposes during the pre‐clinical evaluation …
pharmaceutical companies, for drug screening purposes during the pre‐clinical evaluation …
Recent advances in multicellular tumor spheroid generation for drug screening
KH Lee, TH Kim - Biosensors, 2021 - mdpi.com
Multicellular tumor spheroids (MCTs) have been employed in biomedical fields owing to
their advantage in designing a three-dimensional (3D) solid tumor model. For controlling …
their advantage in designing a three-dimensional (3D) solid tumor model. For controlling …
Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids
S Riffle, RS Hegde - Journal of Experimental & Clinical Cancer Research, 2017 - Springer
Under hypoxic conditions, tumor cells undergo a series of adaptations that promote
evolution of a more aggressive tumor phenotype including the activation of DNA damage …
evolution of a more aggressive tumor phenotype including the activation of DNA damage …
Biomaterials‐based approaches to tumor spheroid and organoid modeling
Evolving understanding of structural and biological complexity of tumors has stimulated
development of physiologically relevant tumor models for cancer research and drug …
development of physiologically relevant tumor models for cancer research and drug …
Hepato (geno) toxicity assessment of nanoparticles in a HepG2 liver spheroid model
(1) In compliance with the 3Rs policy to reduce, refine and replace animal experiments, the
development of advanced in vitro models is needed for nanotoxicity assessment. Cells …
development of advanced in vitro models is needed for nanotoxicity assessment. Cells …
3D culture technologies of cancer stem cells: promising ex vivo tumor models
C Zhang, Z Yang, DL Dong, TS Jang… - Journal of tissue …, 2020 - journals.sagepub.com
Cancer stem cells have been shown to be important in tumorigenesis processes, such as
tumor growth, metastasis, and recurrence. As such, many three-dimensional models have …
tumor growth, metastasis, and recurrence. As such, many three-dimensional models have …
Advanced biomaterials and microengineering technologies to recapitulate the stepwise process of cancer metastasis
Cancer is one of the leading causes of death globally according to the World Health
Organization. Although improved treatments and early diagnoses have reduced cancer …
Organization. Although improved treatments and early diagnoses have reduced cancer …