The thioredoxin (Trx) system is one of the central antioxidant systems in mammalian cells,
maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine …

Significance: Protein S-nitrosylation, the oxidative modification of cysteine by nitric oxide
(NO) to form protein S-nitrosothiols (SNOs), mediates redox-based signaling that conveys, in …

Nitric oxide participates in cellular signal transduction largely through S-nitrosylation of
allosteric and active-site cysteine thiols within proteins, forming S-nitroso-proteins (SNO …

Pancreatic β-cells are responsible for insulin production, and loss of functional β-cell mass is
now recognized as a critical step in the pathogenesis of both type 1 and type 2 diabetes …

Significance: Thioredoxin (Trx) is a powerful antioxidant that reduces protein disulfides to
maintain redox stability in cells and is involved in regulating multiple redox-dependent …

Thioredoxin Interacting Protein (TXNIP) mediates retinal inflammation, gliosis, and apoptosis
in experimental diabetes. Here, we investigate the temporal response of Muller glia to high …

While inflammation is considered a central component in the development in diabetic
nephropathy, the mechanism remains unclear. The NLRP3 inflammasome acts as both a …

Significance: Nitric oxide (NO) regulates a diverse range of cellular processes, including
vasodilation, neurotransmission, and antimicrobial and anti-tumor activities. S-nitrosylation …

Oxidative post-translational modifications of proteins resulting from events that increase
cellular oxidant levels play important roles in physiological and pathophysiological …

Thioredoxin interacting protein (TXNIP) is a metabolism-oxidative-and inflammation-related
marker induced in cardiovascular diseases and is believed to represent a possible link …