Elderly persons are more susceptible to bacterial and virus infections and neoplasias than
young adults. This is related to an impaired immune response. Lymphocytes of the elderly …

Current models suggest that continuous antigenic stimulation of memory B cells is required
to maintain long-term antibody production. In view of recent developments concerning …

In order to study the mechanism by which increasing unsaturation of dietary fat lowers HDL-
cholesterol levels, we studied various measures of HDL metabolism in hamsters fed with fats …

Cytokine synthesis and release is an essential component of the innate immune system, but
inappropriate, excessive production results in a generalized systemic inflammatory …

Mature T lymphocytes expressing the αβ T cell receptor are generally classified as either
CD4+ or CD8+, based on the mutually exclusive expression of these two lymphocyte …

Aging and cancer are highly correlated biological phenomena. Various cellular processes
such as DNA damage responses and cellular senescence that serve as tumor suppressing …

Advanced age has repeatedly been identified as an independent correlate of adverse
outcome and a predictor of mortality in cases of severe acute respiratory syndrome (SARS) …

Congenital patients who lack natural killer (NK) cell activity experience repeated
polymicrobial infections. NK cell activity varies significantly among normal people, but it is …

The CD28 molecule, a disulfide-linked homodimer expressed on peripheral T cells and
thymocytes, mediates an essential costimulatory signal following engagement of the T cell …

The proinflammatory cytokines play a central role in mediating cellular and physiological
responses, and levels may reflect immune system effectiveness. In this study, the effect of …