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PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
A Glaviano, ASC Foo, HY Lam, KCH Yap, W Jacot… - Molecular cancer, 2023 - Springer
Abstract The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …
Deciphering breast cancer: from biology to the clinic
Breast cancer remains a leading cause of cancer-related mortality in women, reflecting
profound disease heterogeneity, metastasis, and therapeutic resistance. Over the last …
profound disease heterogeneity, metastasis, and therapeutic resistance. Over the last …
Towards targeting the breast cancer immune microenvironment
The tumour immune microenvironment is shaped by the crosstalk between cancer cells,
immune cells, fibroblasts, endothelial cells and other stromal components. Although the …
immune cells, fibroblasts, endothelial cells and other stromal components. Although the …
RNA in cancer
While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …
Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis
Abstract The AURORA US Metastasis Project was established with the goal to identify
molecular features associated with metastasis. We assayed 55 females with metastatic …
molecular features associated with metastasis. We assayed 55 females with metastatic …
Mutational signatures: emerging concepts, caveats and clinical applications
Whole-genome sequencing has brought the cancer genomics community into new territory.
Thanks to the sheer power provided by the thousands of mutations present in each patient's …
Thanks to the sheer power provided by the thousands of mutations present in each patient's …
Molecular classification of breast cancer
JYS Tsang, MT Gary - Advances in anatomic pathology, 2020 - journals.lww.com
Cancer classification aims to provide an accurate diagnosis of the disease and prediction of
tumor behavior to facilitate oncologic decision making. Traditional breast cancer …
tumor behavior to facilitate oncologic decision making. Traditional breast cancer …
The genomic landscape of endocrine-resistant advanced breast cancers
We integrated the genomic sequencing of 1,918 breast cancers, including 1,501 hormone
receptor-positive tumors, with detailed clinical information and treatment outcomes. In 692 …
receptor-positive tumors, with detailed clinical information and treatment outcomes. In 692 …
Frequency and spectrum of PIK3CA somatic mutations in breast cancer
Abstract Purpose The therascreen PIK3CA mutation assay and the alpha-specific PI3K
inhibitor alpelisib are FDA-approved for identifying and treating patients with advanced …
inhibitor alpelisib are FDA-approved for identifying and treating patients with advanced …
[HTML][HTML] AKT/PKB signaling: navigating the network
The Ser and Thr kinase AKT, also known as protein kinase B (PKB), was discovered 25
years ago and has been the focus of tens of thousands of studies in diverse fields of biology …
years ago and has been the focus of tens of thousands of studies in diverse fields of biology …