Osteomyelitis, or inflammation of bone, is most commonly caused by invasion of bacterial
pathogens into the skeleton. Bacterial osteomyelitis is notoriously difficult to treat, in part …

Prosthetic Joint Infection (PJI) causes significant morbidity and mortality for patients globally.
Delivery of antibiotics to the site of infection has potential to improve the treatment outcomes …

Objectives Evaluate the role of platelet-rich fibrin (PRF) as a natural carrier for antibiotics
delivery through the analysis of drug release and antimicrobial activity. Materials and …

➤ The current standard of care for late chronic infection is considered to be two-stage
revision arthroplasty including removal of the prosthesis and cement, thorough débridement …

Infections in orthopaedic surgery are a serious issue. Antibiotic‐loaded bone cement was
developed for the treatment of infected joint arthroplasties and for prophylaxes in total joint …

Polymethylmethacrylate (PMMA) has been used in orthopaedics since the 1940s. Despite
the development and popularity of new biomaterials, PMMA remains popular. Although its …

Orthopedic and dental implants have been used successfully for decades to replace or
repair missing or damaged bones, joints, and teeth, thereby restoring patient function …

Antibiotic concentrations associated with antibiotic bone cements may cause skeletal cell
toxicity and prevent fracture healing. We investigated toxicity effects of dose and treatment …

Knowledge about the elution from antibiotic‐loaded cement spacers is an indispensable
premise for guarantee of clinical success. A systematic literature search was performed …

Antibiotic‐loaded bone cement is a primary option for treatment of orthopedic infections.
Poly (methyl methacrylate)(PMMA) is a widely used cement that, when loaded with …