The development of osteoarthritis (OA) correlates with a rise in the number of senescent
cells in joint tissues, and the senescence-associated secretory phenotype (SASP) has been …

Cellular senescence (CS) is one of hallmarks of aging and accumulation of senescent cells
(SCs) with age contributes to tissue or organismal aging, as well as the pathophysiologies of …

Dietary intervention constitutes a feasible approach for modulating metabolism and
improving the health span and lifespan. Methionine restriction (MR) delays the appearance …

Traumatic brain injury (TBI) is associated with mortality and morbidity worldwide.
Accumulating pre-clinical and clinical data suggests TBI is the leading extrinsic cause of …

LMNA encodes nuclear Lamin A/C that tethers lamina-associated domains (LADs) to the
nuclear periphery. Mutations in LMNA cause degenerative disorders including the …

Nuclear structure and function are governed by lamins, which are intermediate filaments that
mostly consist of α-helices. Different lamin assembly models have been proposed based on …

Hutchinson–Gilford progeria syndrome (HGPS) is a rare, invariably fatal childhood
premature aging disorder caused by a pre-messenger RNA (mRNA) splicing defect in the …

Aging, the main risk factor for cardiovascular disease (CVD), is becoming progressively
more prevalent in our societies. A better understanding of how aging promotes CVD is …

Model organisms have provided fundamental evidence that aging can be delayed and
longevity extended. These findings gave rise to a new era in aging research aimed at …

In eukaryotes, precise pre-mRNA processing, including alternative splicing, is essential to
carry out the intricate protein translation process. Both point mutations (that alter the …