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The impact of adult neurogenesis on affective functions: of mice and men
In most mammals, new neurons are not only produced during embryogenesis but also after
birth. Soon after adult neurogenesis was discovered, the influence of recruiting new neurons …
birth. Soon after adult neurogenesis was discovered, the influence of recruiting new neurons …
The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research?
Major depressive disorder (MDD) has until recently been conceptualized as an episodic
disorder associated with 'chemical imbalances' but no permanent brain changes. Evidence …
disorder associated with 'chemical imbalances' but no permanent brain changes. Evidence …
Subcortical volumetric abnormalities in bipolar disorder
Considerable uncertainty exists about the defining brain changes associated with bipolar
disorder (BD). Understanding and quantifying the sources of uncertainty can help generate …
disorder (BD). Understanding and quantifying the sources of uncertainty can help generate …
Neural network of bipolar disorder: Toward integration of neuroimaging and neurocircuit-based treatment strategies
B Bi, D Che, Y Bai - Translational Psychiatry, 2022 - nature.com
Bipolar disorder (BD) is a complex psychiatric disorder characterized by dysfunctions in
three domains including emotional processing, cognitive processing, and psychomotor …
three domains including emotional processing, cognitive processing, and psychomotor …
Hippocampal plasticity in response to exercise in schizophrenia
Context Hippocampal volume is lower than expected in patients with schizophrenia;
however, whether this represents a fixed deficit is uncertain. Exercise is a stimulus to …
however, whether this represents a fixed deficit is uncertain. Exercise is a stimulus to …
Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder
The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar
disorder (BD), a severe mental illness arising from complex interactions between genes and …
disorder (BD), a severe mental illness arising from complex interactions between genes and …
A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder
Background: Some, although not all, studies report small hippocampal volume in patients
with major depressive disorder (MDD) relative to healthy controls. Here, we explore the …
with major depressive disorder (MDD) relative to healthy controls. Here, we explore the …
Can anxiety damage the brain?
Pathological anxiety and chronic stress lead to structural degeneration and impaired
functioning of the hippocampus and the PFC, which may account for the increased risk of …
functioning of the hippocampus and the PFC, which may account for the increased risk of …
Modifiable factors that alter the size of the hippocampus with ageing
The hippocampus is particularly vulnerable to the neurotoxic effects of obesity, diabetes
mellitus, hypertension, hypoxic brain injury, obstructive sleep apnoea, bipolar disorder …
mellitus, hypertension, hypoxic brain injury, obstructive sleep apnoea, bipolar disorder …
Current understandings of the trajectory and emerging correlates of cognitive impairment in bipolar disorder: An overview of evidence
Objectives Cognitive dysfunction affects a significant proportion of people with bipolar
disorder (BD), but the cause, trajectory and correlates of such dysfunction remains unclear …
disorder (BD), but the cause, trajectory and correlates of such dysfunction remains unclear …