Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s),
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …

Peroxisome proliferator‐activated receptor‐γ coactivator (PGC)‐1α is a transcriptional
coactivator described as a master regulator of mitochondrial biogenesis and function …

The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Acute kidney injury (AKI) arising from diverse etiologies is characterized by mitochondrial
dysfunction. The peroxisome proliferator-activated receptor γ coactivator-1alpha (PGC1α), a …

Recent advances have led to a greater appreciation of how mitochondrial dysfunction
contributes to diverse acute and chronic pathologies. Indeed, mitochondria have received …

New types of antidiabetic agents are continually needed with diabetes becoming the
epidemic in the world. Indole alkaloids play an important role in natural products owing to …

As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …

Alterations of hepatic metabolism are critical to the development of liver disease. The
peroxisome proliferator-activated receptor-γ coactivators (PGC1s) are able to orchestrate, on …

Adaptive thermogenesis has attracted much attention because of its ability to increase
systemic energy expenditure and to counter obesity and diabetes,–. Recent data have …

Diabetes mellitus (DM) is a growing health concern in society. Type 1 and type 2 DM are the
two main types of diabetes; both types are chronic diseases that affect glucose metabolism …