[HTML][HTML] Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments

SA Antar, NA Ashour, M Sharaky, M Khattab… - Biomedicine & …, 2023 - Elsevier
Nowadays, diabetes mellitus has emerged as a significant global public health concern with
a remarkable increase in its prevalence. This review article focuses on the definition of …

Methylglyoxal metabolism and aging-related disease: moving from correlation toward causation

R Kold-Christensen, M Johannsen - Trends in Endocrinology & Metabolism, 2020 - cell.com
Methylglyoxal (MG) is a ubiquitous metabolite that spontaneously reacts with biopolymers
forming advanced glycation end-products (AGEs). AGEs are strongly associated with aging …

Hallmarks of metabolic reprogramming and their role in viral pathogenesis

CNS Allen, SP Arjona, M Santerre, BE Sawaya - Viruses, 2022 - mdpi.com
Metabolic reprogramming is a hallmark of cancer and has proven to be critical in viral
infections. Metabolic reprogramming provides the cell with energy and biomass for large …

[HTML][HTML] Molecular mechanisms related to oxidative stress in retinitis pigmentosa

CE Gallenga, M Lonardi, S Pacetti, SS Violanti… - Antioxidants, 2021 - mdpi.com
Retinitis pigmentosa (RP) is an inherited retinopathy. Nevertheless, non-genetic biological
factors play a central role in its pathogenesis and progression, including inflammation …

Exosomes derived from adipose-derived stem cells overexpressing glyoxalase-1 protect endothelial cells and enhance angiogenesis in type 2 diabetic mice with limb …

X Zhang, Y Jiang, Q Huang, Z Wu, H Pu, Z Xu… - Stem Cell Research & …, 2021 - Springer
Background Diabetic limb ischemia is a clinical syndrome and refractory to therapy. Our
previous study demonstrated that adipose-derived stem cells (ADSCs) overexpressing …

Glycation of LDL: AGEs, impact on lipoprotein function, and involvement in atherosclerosis

AV Poznyak, VN Sukhorukov, R Surkova… - Frontiers in …, 2023 - frontiersin.org
Atherosclerosis is a complex disease, and there are many factors that influence its
development and the course of the disease. A deep understanding of the pathological …

Advanced glycation end products and diabetes and other metabolic indicators

T Jiang, Y Zhang, F Dai, C Liu, H Hu… - Diabetology & Metabolic …, 2022 - Springer
Background Diabetes is a global concern among adults. Previous studies have suggested
an association between different screening methods and diabetes; however, increasing …

[HTML][HTML] Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes

D Schumacher, J Morgenstern, Y Oguchi, N Volk… - Molecular …, 2018 - Elsevier
Abstract Objectives The deficit of Glyoxalase I (Glo1) and the subsequent increase in
methylglyoxal (MG) has been reported to be one the five mechanisms by which …

Photo-enhanced chemo-transistor platform for ultrasensitive assay of small molecules

Q Wang, Z Ai, Q Guo, X Wang, C Dai… - Journal of the …, 2023 - ACS Publications
Compared with traditional assay techniques, field-effect transistors (FETs) have advantages
such as fast response, high sensitivity, being label-free, and point-of-care detection, while …

Formation of advanced glycation endproducts in foods during cooking process and underlying mechanisms: a comprehensive review of experimental studies

E Inan-Eroglu, A Ayaz, Z Buyuktuncer - Nutrition research reviews, 2020 - cambridge.org
Advanced glycation endproducts (AGE) are a group of complex and heterogeneous
molecules, sharing some common characteristics such as covalent cross-link formation …