Evolution and implications of de novo genes in humans
Genes and translated open reading frames (ORFs) that emerged de novo from previously
non-coding sequences provide species with opportunities for adaptation. When aberrantly …
non-coding sequences provide species with opportunities for adaptation. When aberrantly …
The functional meaning of 5′ UTR in protein-coding genes
As it is well known, messenger RNA has many regulatory regions along its sequence length.
One of them is the 5′ untranslated region (5'UTR), which itself contains many regulatory …
One of them is the 5′ untranslated region (5'UTR), which itself contains many regulatory …
Translation and natural selection of micropeptides from long non-canonical RNAs
Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides but lacking
canonical coding sequences. Apparently unable to produce peptides, lncRNA function …
canonical coding sequences. Apparently unable to produce peptides, lncRNA function …
What can ribo-seq, immunopeptidomics, and proteomics tell us about the noncanonical proteome?
Abstract Ribosome profiling (Ribo-Seq) has proven transformative for our understanding of
the human genome and proteome by illuminating thousands of noncanonical sites of …
the human genome and proteome by illuminating thousands of noncanonical sites of …
The human DEAD-box helicase DDX3X as a regulator of mRNA translation
CS Ryan, M Schröder - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
The human DEAD-box protein DDX3X is an RNA remodelling enzyme that has been
implicated in various aspects of RNA metabolism. In addition, like many DEAD-box proteins …
implicated in various aspects of RNA metabolism. In addition, like many DEAD-box proteins …
Surviving and adapting to stress: translational control and the integrated stress response
Significance: Organisms adapt to changing environments by engaging cellular stress
response pathways that serve to restore proteostasis and enhance survival. A primary …
response pathways that serve to restore proteostasis and enhance survival. A primary …
Nuclear release of eIF1 restricts start-codon selection during mitosis
Regulated start-codon selection has the potential to reshape the proteome through the
differential production of upstream open reading frames, canonical proteins, and alternative …
differential production of upstream open reading frames, canonical proteins, and alternative …
A small protein coded within the mitochondrial canonical gene nd4 regulates mitochondrial bioenergetics
Background Mitochondria have a central role in cellular functions, aging, and in certain
diseases. They possess their own genome, a vestige of their bacterial ancestor. Over the …
diseases. They possess their own genome, a vestige of their bacterial ancestor. Over the …
Non-canonical start codons confer context-dependent advantages in carbohydrate utilization for commensal E. coli in the murine gut
Resource competition is a driver of gut microbiota composition. Bacteria can outcompete
metabolically similar rivals through the limitation of shared growth-fuelling nutrients. The …
metabolically similar rivals through the limitation of shared growth-fuelling nutrients. The …
A Kuhnian revolution in molecular biology: Most genes in complex organisms express regulatory RNAs
JS Mattick - Bioessays, 2023 - Wiley Online Library
Thomas Kuhn described the progress of science as comprising occasional paradigm shifts
separated by interludes of 'normal science'. The paradigm that has held sway since the …
separated by interludes of 'normal science'. The paradigm that has held sway since the …