The alarming numbers of poorly soluble discovery compounds have centered the efforts
towards finding strategies to improve the solubility. One of the attractive approaches to …

Cocrystals have gained attention in the pharmaceutical industry due to their ability to
improve solubility, stability, in vitro dissolution rate, and bioavailability of poorly soluble …

Dicarboxylic acids (DiAs) are probably among of the most popular cocrystal formers. Due to
the high hydrophilicity and nontoxicity, they are promising solubilizers of active …

Resveratrol (RSV), a dietary polyphenol found in red wine, has renewed interest in recent
years due to a broad range of in vitro evidence that indicate cardioprotective effects. Herein …

New multicomponent crystals of mequitazine (MQZ) with succinic acid (SUC), fumaric acid
(FUM), glycolic acid (GLC), and glycolamide (GLA) were obtained after liquid-assisted …

In this work, the formation of non-solvated crystalline structure [Pd (1, 10-phen)(2, 3, 5, 6-S-
C6F4H) 2] 1 (1, 10-phen= 1, 10-phenanthroline) and three different crystalline …

The synthesized compound (Z)-4-fluoro-N′-(3-fluorophenyl) benzimidamide exhibits
solvatomorphism in the solid state. The anhydrous and the hydrate forms were obtained at …

Improving the solubility of an organic compound. A coc rystal of (1) 6-ethyl-N-[1-
(hydroxyacetyl) piperidin-4-yl]-1 methyl-4-oxo-5-(2-oxo-2-phenylethyl)-3-(2, 2, 2-trifluoro …

In the first part of the thesis, a systematic protocol was proposed to identify mechanisms via
which crystallisation takes place when amorphous drug is dissolved. The stabilisation …

Improving the solubility of an organic compound. A cocrystal of (1) 6-ethyl-N-[1-
(hydroxyacetyl) piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-3-(2, 2, 2 …