Image-based profiling is a maturing strategy by which the rich information present in
biological images is reduced to a multidimensional profile, a collection of extracted image …

Human-induced pluripotent stem cells (hiPSCs) and CRISPR/Cas9 gene editing system
represent two instruments of basic and translational research, which both allow to acquire …

Natural product structure and fragment-based compound development inspire pseudo-
natural product design through different combinations of a given natural product fragment …

Clinical practice shows that when single-target drugs treat multi-factor diseases such as
tumors, cardiovascular system and endocrine system diseases, it is often difficult to achieve …

Chemical probes represent versatile tools to validate disease-modifying targets. However,
evaluating the selectivity of chemical probes in complex cellular systems is a major …

Target‐identification phenotypic screening has been a powerful approach in drug discovery;
however, it is hindered by difficulties in identifying the underlying cellular targets. To address …

Disrupting microtubule dynamics has emerged as a promising strategy for cancer treatment.
However, drug resistance remains a challenge hindering the development of microtubule …

Conventional thinking in modern drug discovery postulates that the design of highly
selective molecules which act on a single disease-associated target will yield safer and …

Research on new cancer drugs is performed either through gene knockout studies or
phenotypic screening of drugs in cancer cell-lines. Both of these approaches are costly and …

Predicting assay results for compounds virtually using chemical structures and phenotypic
profiles has the potential to reduce the time and resources of screens for drug discovery …