DNA-empowered synthetic cells as minimalistic life forms

A Samanta, L Baranda Pellejero, M Masukawa… - Nature Reviews …, 2024‏ - nature.com
Cells, the fundamental units of life, orchestrate intricate functions—motility, adaptation,
replication, communication, and self-organization within tissues. Originating from …

Recent advances in DNA origami-engineered nanomaterials and applications

P Zhan, A Peil, Q Jiang, D Wang, S Mousavi… - Chemical …, 2023‏ - ACS Publications
DNA nanotechnology is a unique field, where physics, chemistry, biology, mathematics,
engineering, and materials science can elegantly converge. Since the original proposal of …

Actuating tension-loaded DNA clamps drives membrane tubulation

L Liu, Q **ong, C **e, F Pincet, C Lin - Science Advances, 2022‏ - science.org
Membrane dynamics in living organisms can arise from proteins adhering to, assembling on,
and exerting force on cell membranes. Programmable synthetic materials, such as self …

Engineering DNA-based cytoskeletons for synthetic cells

K Jahnke, K Göpfrich - Interface Focus, 2023‏ - royalsocietypublishing.org
The development and bottom-up assembly of synthetic cells with a functional cytoskeleton
sets a major milestone to understand cell mechanics and to develop man-made machines …

Liposome-based hybrid drug delivery systems with DNA nanostructures and metallic nanoparticles

O Reinsalu, M Ernits, V Linko - Expert Opinion on Drug Delivery, 2024‏ - Taylor & Francis
Introduction This review discusses novel hybrid assemblies that are based on liposomal
formulations. The focus is on the hybrid constructs that are formed through the integration of …

Functionalized DNA-origami-protein nanopores generate large transmembrane channels with programmable size-selectivity

Q Shen, Q **ong, K Zhou, Q Feng, L Liu… - Journal of the …, 2022‏ - ACS Publications
The DNA-origami technique has enabled the engineering of transmembrane nanopores
with programmable size and functionality, showing promise in building biosensors and …

Biomimetic Multilayered Lipid Nanovesicles for Potent Protein Vaccination

BI Koo, DJ Lee, RT Rahman… - Advanced Healthcare …, 2024‏ - Wiley Online Library
Lipid vesicles are widely used for drug and gene delivery, but their structural instability
reduces in vivo efficacy and requires specialized handling. To address these limitations …

DNA Origami Vesicle Sensors with Triggered Single‐Molecule Cargo Transfer

E Büber, R Yaadav, T Schröder… - Angewandte Chemie …, 2024‏ - Wiley Online Library
Interacting with living systems typically involves the ability to address lipid membranes of
cellular systems. The first step of interaction of a nanorobot with a cell will thus be the …

DNA‐Origami‐Vesikel‐Sensoren für gesteuerten Einzelmolekül‐Frachttransfer

E Büber, R Yaadav, T Schröder… - Angewandte …, 2024‏ - Wiley Online Library
Voraussetzung für Interaktionen mit lebenden Organismen ist in der Regel der Zugang zur
Lipidmembran eines zellulären Systems. Für einen Nanoroboter, der mit einer Zelle …

DNA Origami Vesicle Sensors with Triggered Cargo Transfer

E Büber, R Yaadav, T Schröder, HG Franquelim… - bioRxiv, 2023‏ - biorxiv.org
Interacting with living systems typically involves the ability to address lipid membranes of
cellular systems. The first step of interaction of a nanorobot with a cell will thus be the …