The GBA gene encodes for the lysosomal enzyme glucocerebrosidase (GCase), which
maintains glycosphingolipid homeostasis. Approximately 5–15% of PD patients have …

Neurodegenerative diseases are characterized by the progressive loss of neurons and
intricate interactions between different cell types within the affected regions. Reliable …

The accumulation of proteinaceous inclusions in the brain is a common feature among
neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease (PD), and …

Dysfunction of the endolysosomal system is implicated in the pathogenesis of both sporadic
and familial Parkinson disease (PD). Variants in genes encoding lysosomal proteins have …

GBA gene variants were the first genetic risk factor for Parkinson's disease. GBA encodes
the lysosomal enzyme glucocerebrosidase (GBA), which is involved in sphingolipid …

Sequence variants or mutations in the GBA gene are numerically the most important risk
factor for Parkinson disease (PD). The GBA gene encodes for the lysosomal hydrolase …

Variants in the GBA1 and LRRK2 genes are the most common genetic risk factors
associated with Parkinson disease (PD). Both genes are associated with lysosomal and …

Parkinson's disease (PD) is caused by the degeneration of dopaminergic neurons due to an
accumulation of intraneuronal abnormal alpha-synuclein (α-syn) protein aggregates. It has …

In Parkinson's disease (PD) patients, a wide range of ocular and visual disorders are
present. Tear film instability, inflammation and dysfunction of the ocular surface, and the …

Although the factors contributing to the pathogenesis of neurodegenerative diseases remain
elusive, endolysosomal pathway is emerging as a key player in the pathogenesis of …