Sepsis remains a major cause of morbidity and mortality in both low-and high-income
countries. Antibiotic therapy and supportive care have significantly improved survival …

The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with
devastating consequences. While the medical community has gained insight into the …

Since the initial COVID-19 outbreak in China, much attention has focused on people with
diabetes because of poor prognosis in those with the infection. Initial reports were mainly on …

Proper management of COVID-19 mandates better understanding of disease pathogenesis.
The sudden clinical deterioration 7–8 days after initial symptom onset suggests that severe …

Key Points Sepsis and Septic Shock Sepsis is a syndrome of life-threatening acute organ
dysfunction due to bacterial, fungal, parasitic, or viral infection. Factors that affect the risk of …

Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome
induced by aberrantly activated macrophages and cytotoxic T cells. The primary (genetic) …

Objective Haemophagocytic lymphohistiocytosis (HLH) and macrophage activation
syndrome (MAS) are life-threatening systemic hyperinflammatory syndromes that can …

Sepsis is characterised by a dysregulated host immune response to infection. Despite
recognition of its significance, immune status monitoring is not implemented in clinical …

Background A subset of patients with severe COVID-19 develop a hyperinflammatory
syndrome, which might contribute to morbidity and mortality. This study explores a specific …

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathologic immune activation,
often associated with genetic defects of lymphocyte cytotoxicity. Though a distinctive …