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Going the extra (synaptic) mile: excitotoxicity as the road toward neurodegenerative diseases
Excitotoxicity is a phenomenon that describes the toxic actions of excitatory
neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of …
neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of …
Neurodegenerative diseases–is metabolic deficiency the root cause?
Neurodegenerative diseases, including Alzheimer, Parkinson, Huntington, and amyotrophic
lateral sclerosis, are a prominent class of neurological diseases currently without a cure …
lateral sclerosis, are a prominent class of neurological diseases currently without a cure …
Glutamate uptake
Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …
glutamate transporter proteins present in the plasma membranes of both glial cells and …
Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease
MR Hynd, HL Scott, PR Dodd - Neurochemistry international, 2004 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia, accounting for 60–70% of
cases in subjects over 65 years of age. Several postulates have been put forward that relate …
cases in subjects over 65 years of age. Several postulates have been put forward that relate …
Alzheimer's disease: targeting the glutamatergic system
ME Conway - Biogerontology, 2020 - Springer
Alzheimer's disease (AD) is a debilitating neurodegenerative disease that causes a
progressive decline in memory, language and problem solving. For decades mechanism …
progressive decline in memory, language and problem solving. For decades mechanism …
Memantine and cholinesterase inhibitors: complementary mechanisms in the treatment of Alzheimer's disease
CG Parsons, W Danysz, A Dekundy, I Pulte - Neurotoxicity research, 2013 - Springer
This review describes the preclinical mechanisms that may underlie the increased
therapeutic benefit of combination therapy—with the N-methyl-d-aspartate receptor …
therapeutic benefit of combination therapy—with the N-methyl-d-aspartate receptor …
Mitochondria and neuronal survival
Mitochondria play a central role in the survival and death of neurons. The detailed
bioenergetic mechanisms by which isolated mitochondria generate ATP, sequester Ca2+ …
bioenergetic mechanisms by which isolated mitochondria generate ATP, sequester Ca2+ …
Aging, energy, and oxidative stress in neurodegenerative diseases
The etiology of neurodegenerative diseases remains enigmatic; however, evidence for
defects in energy metabolism, excitotoxicity, and for oxidative damage is increasingly …
defects in energy metabolism, excitotoxicity, and for oxidative damage is increasingly …
Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?
Glutamate N-methyl-D-aspartate (NMDA) receptor antagonists (competitive receptor
antagonists, ion channel blockers, and glycine antagonists)—such as selfotel, aptiganel …
antagonists, ion channel blockers, and glycine antagonists)—such as selfotel, aptiganel …
Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system-too little activation is bad, too much is even …
CG Parsons, A Stöffler, W Danysz - Neuropharmacology, 2007 - Elsevier
The neurotransmitter glutamate activates several classes of metabotropic receptor and three
major types of ionotropic receptor–α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid …
major types of ionotropic receptor–α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid …