The impact of the development of sulfur therapeutics is instrumental to the evolution of the
pharmaceutical industry. Sulfur-derived functional groups can be found in a broad range of …

The global pandemic of drug-sensitive cancers and the increasing threat from drug-resistant
cancers make an urgent need to develop more effective anti-cancer candidates. Quinolone …

The adenosine A1 receptor (A1R) is a promising therapeutic target for non-opioid analgesic
agents to treat neuropathic pain,. However, development of analgesic orthosteric A1R …

The continuous emergency of drug‐resistant cancers and the low specificity of anticancer
agents have been the major challenges in the control and treatment of cancer, making an …

Structural analogs of bisphenol A are commonly used as its alternatives in industrial and
commercial applications. Nevertheless, the question arises whether the use of other …

A simple cobalt (II)/N-hydroxyphthalimide catalyst system has been identified for selective
conversion of benzylic methylene groups in pharmaceutically relevant (hetero) arenes to the …

Drug discovery and development is a complex and lengthy enterprise that suffers from high
rates of candidate attrition at all stages of the process. The physical, biological, and …

The photooxidative desulfurization of thiophene (ThP) becomes a challenge in both industry
and environmental remediation. Herein, we synthesize a visible-light-responsive Ag 2 WO …

G protein-coupled receptors (GPCRs) signal through both G-protein-dependent and G-
protein-independent pathways, and β-arrestin recruitment is the most recognized one of the …

Although idiosyncratic adverse drug reactions are rare, they are still a major concern to
patient safety. Reactive metabolites are widely accepted as playing a pivotal role in the …