Supramolecular hydrogelators and hydrogels: from soft matter to molecular biomaterials

X Du, J Zhou, J Shi, B Xu - Chemical reviews, 2015 - ACS Publications
In this review we intend to provide a relatively comprehensive summary of the work of
supramolecular hydrogelators after 2004 and to put emphasis particularly on the …

Amino acids and peptide‐based supramolecular hydrogels for three‐dimensional cell culture

XQ Dou, CL Feng - Advanced Materials, 2017 - Wiley Online Library
Supramolecular hydrogels assembled from amino acids and peptide‐derived hydrogelators
have shown great potential as biomimetic three‐dimensional (3D) extracellular matrices …

Mechanisms and consequences of macromolecular phase separation

LP Bergeron-Sandoval, N Safaee, SW Michnick - Cell, 2016 - cell.com
Over a century ago, colloidal phase separation of matter into non-membranous bodies was
recognized as a fundamental organizing principal of cell" protoplasm." Recent insights into …

Cancer cell death induced by the intracellular self-assembly of an enzyme-responsive supramolecular gelator

A Tanaka, Y Fukuoka, Y Morimoto… - Journal of the …, 2015 - ACS Publications
We report cancer cell death initiated by the intracellular molecular self-assembly of a peptide
lipid, which was derived from a gelator precursor. The gelator precursor was designed to …

Controlling cancer cell fate using localized biocatalytic self-assembly of an aromatic carbohydrate amphiphile

RA Pires, YM Abul-Haija, DS Costa… - Journal of the …, 2015 - ACS Publications
We report on a simple carbohydrate amphiphile able to self-assemble into nanofibers upon
enzymatic dephosphorylation. The self-assembly can be triggered by alkaline phosphatase …

[HTML][HTML] Considerations for the design and reporting of enzyme assays in high-throughput screening applications

MG Acker, DS Auld - Perspectives in Science, 2014 - Elsevier
This review describes the key steps and methods which are used to develop enzyme assays
suitable for high-throughput screening (HTS) applications. The goals of HTS enzyme assays …

Enhancing calvarial defects repair with PDGF-BB mimetic peptide hydrogels

X Wu, M Yan, J Shen, Y **ang, K Jian, X Pan… - Journal of Controlled …, 2024 - Elsevier
Addressing bone defects represents a significant challenge to public health. Localized
delivery of growth factor has emerged as promising approach for bone regeneration …

Enzyme‐instructed intracellular molecular self‐assembly to boost activity of cisplatin against drug‐resistant ovarian cancer cells

J Li, Y Kuang, J Shi, J Zhou, JE Medina… - Angewandte Chemie …, 2015 - Wiley Online Library
Anticancer drug resistance demands innovative approaches that boost the activity of drugs
against drug‐resistant cancers without increasing the systemic toxicity. Here we show the …

Enzyme-instructed assembly and disassembly processes for targeting downregulation in cancer cells

Z Feng, H Wang, R Zhou, J Li, B Xu - Journal of the American …, 2017 - ACS Publications
Cancer cells differ from normal cells in both gain of functions (ie, upregulation) and loss of
functions (ie, downregulation). While it is common to suppress gain of function for …

[HTML][HTML] Learning from our mistakes: The 'unknown knowns' in fragment screening

BJ Davis, DA Erlanson - Bioorganic & medicinal chemistry letters, 2013 - Elsevier
In the past 15 years, fragment-based lead discovery (FBLD) has been adopted widely
throughout academia and industry. The approach entails discovering very small molecular …