Liver cancer most commonly develops in patients with chronic liver disease, the etiology of
which includes viral hepatitis (B and C), alcohol, obesity, dietary carcinogens, and so forth …

Cancer is a black spot on the face of humanity in this era of science and technology.
Presently, several classes of anticancer drugs are available in the market, but issues such …

Imidazole ring is an important five‐membered aromatic heterocycle widely present in natural
products and synthetic molecules. The unique structural feature of imidazole ring with …

Introduction Cancer has been identified as one of the leading causes of death worldwide.
The biological target of some anticancer agents is topoisomerase I, an enzyme involved in …

Topoisomerase I (Topo I) is a nuclear enzyme engaged in adjustment of DNA topological
structure during cell cycle by cleaving and reannealing one of the two strands of the DNA …

Introduction: Topoisomerases (topos) are nuclear enzymes that resolve topological
problems associated with DNA during various genetic processes. The essential role of topos …

Introduction Topoisomerases are important targets for therapeutic improvement in the
treatment of some diseases, including cancer. Inhibitors and poisons of topoisomerase I can …

Topoisomerases are DNA processing enzymes that relieve supercoiling (torsional strain) in
DNA, are necessary for normal cellular division, and act by nicking (and then religating) …

Hydroxylated analogues of the anticancer topoisomerase I (Top1) inhibitors indotecan
(LMP400) and indimitecan (LMP776) have been prepared because (1) a variety of potent …

Topoisomerase I (topo I) is an essential enzyme for vital cellular processes. Inhibition of topo
I activities is lethal and leads to cell death, thus establishing topo I as a promising target for …