Advanced glycation end products (AGEs) are potentially harmful and heterogeneous
molecules derived from nonenzymatic glycation. The pathological implications of AGEs are …

It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …

Advanced glycation end-products are a complex and heterogeneous group of compounds
that have been implicated in diabetes related complications. At present it is not known if they …

Context: Diabetic complications appear to be multifactorial in origin, but in particular, the
biochemical process of advanced glycation, which is accelerated in diabetes as a result of …

Diabetic nephropathy is characterized by excessive deposition of extracellular matrix
proteins in the mesangium and basement membrane of the glomerulus and in the renal …

Diabetic kidney disease, commonly termed diabetic nephropathy (DN), is the most common
cause of end-stage kidney disease (ESKD) worldwide. The characteristic histopathology of …

The role of vascular endothelial growth factor (VEGF) in renal pathophysiology. Vascular
endothelial growth factor (VEGF) is an endothelial-specific growth factor that promotes …

Diabetic nephropathy ensues from events involving earliest changes in the glomeruli and
podocytes, followed by accumulation of extracellular matrix in the mesangium. Postulated …

The adverse long‐term effects of diabetes mellitus have been well described and involve
many organ systems. While diabetes management has largely focused on control of …

About 246 million people worldwide had diabetes in 2007. The global figure of people with
diabetes is projected to increase to 370 million in 2030. As the prevalence of diabetes has …