Mechanisms of mechanotransduction and physiological roles of PIEZO channels

B ** of the surface interactome of PIEZO1 identifies CADM1 as a modulator of channel inactivation
AK Koster, O Yarishkin, AE Dubin, JM Kefauver… - Proceedings of the …, 2024 - pnas.org
The propeller-shaped blades of the PIEZO1 and PIEZO2 ion channels partition into the
plasma membrane and respond to indentation or stretching of the lipid bilayer, thus …

Joining forces: crosstalk between mechanosensitive PIEZO1 ion channels and integrin-mediated focal adhesions

D Cheng, J Wang, M Yao, CD Cox - Biochemical Society …, 2023 - portlandpress.com
Both integrin-mediated focal adhesions (FAs) and mechanosensitive ion channels such as
PIEZO1 are critical in mechanotransduction processes that influence cell differentiation …

[HTML][HTML] Mechanisms of PIEZO channel inactivation

Z Zhou, B Martinac - International Journal of Molecular Sciences, 2023 - mdpi.com
PIEZO channels PIEZO1 and PIEZO2 are the newly identified mechanosensitive, non-
selective cation channels permeable to Ca2+. In higher vertebrates, PIEZO1 is expressed …

Pharmacology of PIEZO1 channels

JA Kinsella, M Debant, G Parsonage… - British journal of …, 2024 - Wiley Online Library
PIEZO1 is a eukaryotic membrane protein that assembles as trimers to form calcium‐
permeable, non‐selective cation channels with exquisite capabilities for mechanical force …

Piezo1 and its function in different blood cell lineages

AI Karkempetzaki, K Ravid - Cells, 2024 - mdpi.com
Mechanosensation is a fundamental function through which cells sense mechanical stimuli
by initiating intracellular ion currents. Ion channels play a pivotal role in this process by …

Piezo ion channels: long-sought-after mechanosensors mediating hypertension and hypertensive nephropathy

T Nagase, M Nagase - Hypertension Research, 2024 - nature.com
Recent advances in mechanobiology and the discovery of mechanosensitive ion channels
have opened a new era of research on hypertension and related diseases. Piezo1 and …

The activation thresholds and inactivation kinetics of poking-evoked PIEZO1 and PIEZO2 currents are sensitive to subtle variations in mechanical stimulation …

N Zeitzschel, SG Lechner - Channels, 2024 - Taylor & Francis
ABSTRACT PIEZO1 and PIEZO2 are mechanically activated ion channels that confer
mechanosensitivity to various cell types. PIEZO channels are commonly examined using the …