Insulin resistance (IR) plays a crucial role in the development and progression of
metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty …

Lysophosphatidylcholine (LPC) is increasingly recognized as a key marker/factor positively
associated with cardiovascular and neurodegenerative diseases. However, findings from …

Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

The coordination of nutrient sensing, delivery, uptake and utilization is essential for
maintaining cellular, tissue and whole-body homeostasis. Such synchronization can be …

Diabetic retinopathy (DR) is one of the leading causes of visual impairment in the working-
age population. DR is a progressive eye disease caused by long-term accumulation of …

Cancer and metabolic disorders have emerged as major global health challenges, reaching
epidemic levels in recent decades. Often viewed as separate issues, metabolic disorders …

Autotaxin (ATX) is a secreted glycoprotein, widely present in biological fluids including
blood. ATX catalyzes the hydrolysis of lysophosphatidylcholine (LPC) to lysophosphatidic …

Depression and obesity are both common disorders currently affecting public health,
frequently occurring simultaneously within individuals, and the relationship between these …

Aim The worldwide increase in obesity and type 2 diabetes (T2D) represents a major health
challenge. Chronically altered lipids induced by obesity further promote the development of …

Autotaxin (ATX) is the only enzyme of the ecto-nucleotide pyrophosphatase/
phosphodiesterase (ENPP2) family with lysophospholipase D (lysoPLD) activity, which is …